7-ISOPROPOXY-6-METHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBONITRILE

Base Information

• Chemical Name: 7-ISOPROPOXY-6-METHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBONITRILE
• CAS No.: 319492-96-1
• Molecular Formula: C14H14N2O3
• Molecular Weight: 258.277
• Mol file: 319492-96-1.mol

Synonyms:7-ISOPROPOXY-6-METHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBONITRILE;1,4-Dihydro-6-methoxy-7-isopropoxy-4-oxo-3-quinolinecarbonitrile;3-Quinolinecarbonitrile, 1,4-dihydro-6-Methoxy-7-(1-Methylethoxy)-4-oxo-

Chemical Property of 7-ISOPROPOXY-6-METHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBONITRILE

Chemical Property:

• Vapor Pressure: 1.06E-06mmHg at 25°C
• Boiling Point: 402.9°C at 760 mmHg
• PKA: 2.82±0.50(Predicted)
• Flash Point: 197.5°C
• PSA: 75.11000
• Density: 1.25g/cm³
• LogP: 2.19558

Purity/Quality:

98%,99%, ^*data from raw suppliers

7-Isopropoxy-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-ISOPROPOXY-6-METHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBONITRILE

There total 5 articles about 7-ISOPROPOXY-6-METHOXY-4-OXO-1,4-DIHYDRO-QUINOLINE-3-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.3%

2-cyano-3-(3-isopropyloxy-4-methoxyphenylamino)acrylic acid ethyl ester (1043904-24-0) → 7-isopropyloxy-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (319492-96-1)

Guidance literature:

In diphenylether; at 225 ℃; for 0.5h; Microwave irradiation;

DOI:10.1080/00397910902906503

Reference yield:

4-hydroxy-3-methoxybenzoic acid methyl ester (3943-74-6) → 7-isopropyloxy-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (319492-96-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: HNO₃

2.1: Fe; NH₄Cl

3.2: n-BuLi

With nitric acid; iron; ammonium chloride; 1.1: Alkylation / 2.1: Nitration / 3.1: Reduction / 4.1: Condensation;

DOI:10.1016/S0960-894X(00)00493-5

Reference yield:

methyl 4-isopropoxy-3-methoxybenzoate (3535-27-1) → 7-isopropyloxy-6-methoxy-4-oxo-1,4-dihydroquinoline-3-carbonitrile (319492-96-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: HNO₃

2.1: Fe; NH₄Cl

3.2: n-BuLi

With nitric acid; iron; ammonium chloride; 1.1: Nitration / 2.1: Reduction / 3.1: Condensation;

DOI:10.1016/S0960-894X(00)00493-5

upstream raw materials:

N,N-dimethyl-formamide dimethyl acetal

acetonitrile

methyl 2-amino-4-isopropoxy-5-methoxybenzoate

4-hydroxy-3-methoxybenzoic acid methyl ester

Downstream raw materials:

7-(3-chloro-propoxy)-4-chloro-6-methoxy-quinoline-3-carbonitrile

4-chloro-7-hydroxy-6-methoxyquinolin-3-carbonitrile

7-isopropyloxy-6-methoxy-4-chloroquinoline-3-carbonitrile