Donepezil Impurity

Base Information

• Chemical Name: Donepezil Impurity
• CAS No.: 844694-84-4
• Molecular Formula: C24H31NO2
• Molecular Weight: 365.50800
• Mol file: 844694-84-4.mol

Synonyms:Piperidine, 4-[(2,3-dihydro-5,6-dimethoxy-1H-inden-2-yl)methyl]-1-(phenylmethyl)-;

Chemical Property of Donepezil Impurity

Chemical Property:

• Boiling Point: 485.5±45.0 °C(Predicted)
• PKA: 8.95±0.10(Predicted)
• PSA: 21.70000
• Density: 1.087±0.06 g/cm3(Predicted)
• LogP: 4.65880

Purity/Quality:

99.0% Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Donepezil Impurity

There total 1 articles about Donepezil Impurity which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride (1034439-43-4) + benzaldehyde (100-52-7) → 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindane (844694-84-4)

Guidance literature:

With sodium cyanoborohydride; In methanol; acetic acid; at 20 ℃; for 16h;

DOI:10.1021/jm8001313

Reference yield:

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindane (844694-84-4) → 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindane hydrochloride (1034439-57-0)

Guidance literature:

With hydrogenchloride; In methanol; dichloromethane;

DOI:10.1021/jm8001313

upstream raw materials:

5,6-dimethoxy-2-[(4-piperidinyl)methyl]indane hydrochloride

benzaldehyde

Downstream raw materials:

2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindane hydrochloride