Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate

Base Information

• Chemical Name: Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate
• CAS No.: 1222172-50-0
• Molecular Formula: C15H17N3O4
• Molecular Weight: 303.318
• Mol file: 1222172-50-0.mol

Synonyms:Benzoic acid, 5-(acetylamino)-2-[(2-cyanoethenyl)amino]-4-ethoxy-, methyl ester;

Chemical Property of Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate

There total 8 articles about Methyl 5-acetamido-2-{[(E)-2-cyanovinyl]amino}-4-ethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3,3-bis(ethyloxy)propanenitrile (2032-34-0) + methyl 5-acetamido-2-amino-4-ethoxybenzoate (1222172-49-7) → methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate (1222172-50-0)

Guidance literature:

3,3-bis(ethyloxy)propanenitrile; With water; trifluoroacetic acid; at 20 ℃; for 12h;

methyl 5-acetamido-2-amino-4-ethoxybenzoate; In ethyl acetate; at 20 ℃; Product distribution / selectivity;

Reference yield: 94.8%

3-dimethylaminoacrylonitrile (2407-68-3) + methyl 5-acetamido-2-amino-4-ethoxybenzoate (1222172-49-7) → methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate (1222172-50-0)

Guidance literature:

methyl 5-acetamido-2-amino-4-ethoxybenzoate; acetic acid; at 20 ℃;

3-dimethylaminoacrylonitrile; at 25 - 30 ℃; Product distribution / selectivity;

Reference yield: 92.4%

3-(morpholin-4-yl)acrylonitrile (5817-82-3) + methyl 4-ethoxy-5-acetylamido-2-aminobenzoate hydrochloride → methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate (1222172-50-0)

Guidance literature:

methyl 4-ethoxy-5-acetylamido-2-aminobenzoate hydrochloride; acetic acid; at 20 ℃;

3-(morpholin-4-yl)acrylonitrile; for 1.3h;

upstream raw materials:

3,3-bis(ethyloxy)propanenitrile

methyl 5-acetamido-2-amino-4-ethoxybenzoate

cyanoacetaldehyde

methyl 5-acetamido-4-ethoxy-2-nitrobenzoate

Downstream raw materials:

7-ethoxy-6-acetylamino-4-chloro-quinoline-3-carbonitrile

3-cyano-4-hydroxyl-6-acetamido-7-ethoxyquinoline

N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide