N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide

Base Information

Chemical Name:N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
CAS No.:848133-75-5
Molecular Formula:C14H13N3O3
Molecular Weight:271.276
Hs Code.:2933499090
European Community (EC) Number:812-950-0
UNII:V9QP8N7N8G
DSSTox Substance ID:DTXSID40466621
Nikkaji Number:J2.998.777G
Wikidata:Q72458100
Mol file:848133-75-5.mol

Synonyms:848133-75-5;N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide;1201080-09-2;N-(3-CYANO-7-ETHOXY-4-OXO-1,4-DIHYDROQUINOLIN-6-YL)ACETAMIDE;N-(3-cyano-7-ethoxy-4-oxo-1H-quinolin-6-yl)acetamide;Acetamide, N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-;V9QP8N7N8G;Intermediate 1(KK-04-01);3-CYANO-7-ETHOXY-4-HYDROXY-6-N-ACETYLQUINOLINE;N-(3-Cyano-7-ethoxy-1,4-dihydro-4-oxo-6-quinolinyl)acetamide;Acetamide, N-(3-cyano-7-ethoxy-1,4-dihydro-4-oxo-6-quinolinyl)-;UNII-V9QP8N7N8G;SCHEMBL2543431;DTXSID40466621;OVURAHRGGCJNEB-UHFFFAOYSA-N;BCP07691;YIB13375;AKOS015960196;AB49249;DS-7492;CS-0001164;FT-0741658;3-cyano-7-ethoxy-4-hydroxy-6-acetylamino quinoline;N-(3-cyano-7-ethoxy-4-hydroxy-6-quinolinyl)-Acetamide,

Suppliers and Price of N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynChem
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95+%
5 g
$ 2175.00

SynChem
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95+%
1 g
$ 550.00

Crysdot
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95+%
5g
$ 1129.00

Crysdot
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95+%
1g
$ 376.00

Chemenu
N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95%
1g
$ 355.00

Chemenu
N-(3-cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95%
5g
$ 1066.00

American Custom Chemicals Corporation
3-CYANO-7-ETHOXY-4-HYDROXY-6-N-ACETYLQUINOLINE 95.00%
5MG
$ 495.59

Alichem
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
5g
$ 1174.20

Alichem
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
1g
$ 380.00

Alichem
N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide
250mg
$ 152.00

Total 44 raw suppliers

Chemical Property of N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Melting Point:>250℃
Refractive Index:1.61
Boiling Point:481.433 °C at 760 mmHg
PKA:0.84±0.50(Predicted)
Flash Point:244.962 °C
PSA：95.24000
Density:1.331 g/cm³
LogP:2.24218
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:271.09569129
Heavy Atom Count:20
Complexity:491

Purity/Quality:

97% ^*data from raw suppliers

N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=C(C=C2C(=C1)NC=C(C2=O)C#N)NC(=O)C

Technology Process of N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide

There total 61 articles about N-(3-Cyano-7-ethoxy-4-hydroxyquinolin-6-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1201079-53-9
5-acetamido-2-amino-4-ethoxybenzoylacetonitrile

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1201080-09-2,848133-75-5
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

Guidance literature:: In 1,2-dimethoxyethane; at 15 - 30 ℃; for 1h;
DOI:10.1002/jhet.1901

Reference yield: 85.0%

: 1222172-50-0
methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate

: 1201080-09-2,848133-75-5
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

Guidance literature:: methyl 5-acetamido-2-[(2-cyanovinyl)amino]-4-ethoxybenzoate; With sodium t-butanolate; In tert-butyl alcohol; for 3h; Reflux; Large scale;

With hydrogenchloride; In water; at 40 - 50 ℃; for 1h; pH=Ca. 4; Reagent/catalyst; Large scale;
DOI:10.1021/op300260m

Reference yield: 75.0%

: N-(3-bromo-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

: 544-92-3
copper(I) cyanide

: 1201080-09-2,848133-75-5
N-(3-cyano-7-ethoxy-4-oxo-1,4-dihydroquinolin-6-yl)acetamide

Guidance literature:: With copper(l) iodide; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 6h; Inert atmosphere;
DOI:10.1080/00304948.2015.1005987