1H-Indazole-6-carboxylic acid, 5-bromo-, methyl ester

Base Information

Chemical Name:1H-Indazole-6-carboxylic acid, 5-bromo-, methyl ester
CAS No.:1000342-30-2
Molecular Formula:C9H7BrN2O2
Molecular Weight:255.06808
Hs Code.:2933990090
Mol file:1000342-30-2.mol

Synonyms:1H-Indazole-6-carboxylic acid, 5-broMo-, Methyl ester;Methyl 5-bromo-1H-indazole-6-carboxylate;5-Bromo-1H-indazole-6-carboxylic acid methyl ester

Suppliers and Price of 1H-Indazole-6-carboxylic acid, 5-bromo-, methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl 5-bromo-1H-indazole-6-carboxylate
50mg
$ 65.00

SynQuest Laboratories
Methyl 5-bromo-1H-indazole-6-carboxylate 96%
250 mg
$ 55.00

SynQuest Laboratories
Methyl 5-bromo-1H-indazole-6-carboxylate 96%
1 g
$ 125.00

Sigma-Aldrich
Methyl 5-bromo-1H-indazole-6-carboxylate 95%
1g
$ 120.00

Matrix Scientific
Methyl 5-bromo-1H-indazole-6-carboxylate >97%
1g
$ 169.00

Crysdot
Methyl 5-bromo-1H-indazole-6-carboxylate 97%
1g
$ 97.00

Crysdot
Methyl 5-bromo-1H-indazole-6-carboxylate 97%
5g
$ 335.00

Chemenu
Methyl 5-bromo-1H-indazole-6-carboxylate 97%
5g
$ 308.00

Chemcia Scientific
5-Bromo-1H-indazole-6-carboxylicacidmethylester 95%
10 G
$ 585.00

Chemcia Scientific
5-Bromo-1H-indazole-6-carboxylicacidmethylester 95%
5 G
$ 345.00

Total 24 raw suppliers

Chemical Property of 1H-Indazole-6-carboxylic acid, 5-bromo-, methyl ester

Chemical Property:

Boiling Point:391.9±22.0 °C(Predicted)
PKA:11.17±0.40(Predicted)
PSA：54.98000
Density:1.709±0.06 g/cm3(Predicted)
LogP:2.11200
Storage Temp.:Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

Methyl 5-bromo-1H-indazole-6-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Indazole-6-carboxylic acid, 5-bromo-, methyl ester

There total 2 articles about 1H-Indazole-6-carboxylic acid, 5-bromo-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 474330-54-6
5-amino-2-bromo-4-methylbenzoic acid methyl ester

: 1000342-30-2
methyl 5-bromo-1H-indazole-6-carboxylate

Guidance literature:: 5-amino-2-bromo-4-methylbenzoic acid methyl ester; With tert.-butylnitrite; boron trifluoride diethyl etherate; In dichloromethane; at -78 - 20 ℃; Inert atmosphere;

With 18-crown-6 ether; potassium acetate; In dichloromethane; at 20 ℃;
DOI:10.1021/jm401986p

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1000342-30-2
methyl 5-bromo-1H-indazole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 20 °C / Cooling with ice

2.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere

2.2: 20 °C

With N-Bromosuccinimide; tert.-butylnitrite; boron trifluoride diethyl etherate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401986p

Reference yield:

: 1000342-30-2
methyl 5-bromo-1H-indazole-6-carboxylate

: methyl 3-[[5-(3,4-difluorophenyl)-1-tetrahydropyran-2-yl-6-tetrahydropyran-4-ylpyrazolo[4,3-g]isoquinolin-8-yl]amino]cyclobutanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 0.33 h / 20 °C

2.1: diisobutylaluminium hydride / dichloromethane / 1.25 h / -78 °C

3.1: sodium hydrogencarbonate; sodium bromide; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; sodium perchlorate / dichloromethane; water / 1.33 h / 3 - 6 °C

4.1: triethylamine / water; 1,4-dioxane / 0.25 h / 50 °C / Inert atmosphere

4.2: 6 h / 50 °C / Inert atmosphere

5.1: hydroxylamine hydrochloride; pyridine / acetonitrile / 1 h / 20 °C

6.1: iodine; potassium carbonate / dichloromethane / 1 h / 20 °C

7.1: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 1 h / 125 °C / Inert atmosphere; Microwave irradiation

8.1: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 80 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydroxylamine hydrochloride; 4-acetylamino-2,2,6,6-tetramethyl-1-piperidinoxy; sodium perchlorate; iodine; diisobutylaluminium hydride; sodium hydrogencarbonate; sodium carbonate; potassium carbonate; toluene-4-sulfonic acid; triethylamine; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; sodium bromide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;