2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester

Base Information

Chemical Name:2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester
CAS No.:1186223-50-6
Molecular Formula:C11H13F2NO4S
Molecular Weight:293.291
Hs Code.:
Mol file:1186223-50-6.mol

Synonyms:2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester;methyl 2,6-difluoro-3-[(propylsulfonyl)amino]benzoate

Suppliers and Price of 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester

Chemical Property:

PSA：80.85000
LogP:3.05690

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester

There total 9 articles about 2,6-Difluoro-3-[(propylsulfonyl)amino]benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1186193-95-2
methyl 2,6-difluoro-3-(N-(propylsulfonyl)propylsulfonamido)benzoate

: 1186223-50-6
methyl 2,6-difluoro-3-(propylsulfonamido)benzoate

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2012.12.027

Reference yield: 54.0%

: 10147-36-1
n-propanesulfonyl chloride

: 84832-02-0
methyl 3-amino-2,6-difluorobenzoate

: 1186223-50-6
methyl 2,6-difluoro-3-(propylsulfonamido)benzoate

Guidance literature:: With pyridine; In 1,2-dichloro-ethane; at 100 ℃; for 5h;

Reference yield:

: 84832-01-9
methyl 2,6-difluoro-3-nitrobenzoate

: 1186223-50-6
methyl 2,6-difluoro-3-(propylsulfonamido)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 22 h / 2585.81 Torr

2: triethylamine / dichloromethane / 1 h / 0 - 20 °C

3: sodium hydroxide / tetrahydrofuran; methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2012.12.027