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918523-58-7

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918523-58-7 Usage

General Description

N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide, also known as DFP, is a chemical compound with the formula C9H12F2N2O2S. It is an organofluorine compound that belongs to the class of sulfonamide compounds. DFP is commonly used in the pharmaceutical industry as a potential lead compound for the development of new drugs due to its biological activity. N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide has been studied for its potential applications in the treatment of various diseases, including cancer and bacterial infections. Its chemical structure and properties make it a promising candidate for further research and development in the field of medicinal chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 918523-58-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,8,5,2 and 3 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 918523-58:
(8*9)+(7*1)+(6*8)+(5*5)+(4*2)+(3*3)+(2*5)+(1*8)=187
187 % 10 = 7
So 918523-58-7 is a valid CAS Registry Number.

918523-58-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name N-(2,4-difluoro-3-formylphenyl)propane-1-sulfonamide

1.2 Other means of identification

Product number -
Other names N-(2,4-Difluoro-3-formylphenyl)-1-propanesulfonamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:918523-58-7 SDS

918523-58-7Downstream Products

918523-58-7Relevant articles and documents

PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH

-

, (2019/08/26)

The invention relates to pyrazolo-pyridine compounds which inhibit mitogen-activated protein kinase kinase 4 (MKK4) and in particular, selectively inhibit MKK4 over protein kinases JNK1 and MKK7. The compounds are useful for promoting liver regeneration or reducing or preventing hepatocyte death. They are further useful for treating osteoarthritis or rheumatoid arthritis, or CNS-related diseases.

Rapid, microwave-assisted organic synthesis of selective V600EBRAF inhibitors for preclinical cancer research

Buck, Jason R.,Saleh, Sam,Imam Uddin, Md.,Manning, H. Charles

, p. 4161 - 4165 (2012/08/29)

We report dramatically improved total syntheses of two highly selective V600EBRAF inhibitors, PLX4720 and PLX4032, that leverages microwave-assisted organic synthesis (MAOS). Compared with previously reported approaches, our novel MAOS method significantly reduces overall reaction time without compromising yield. In addition to providing a gram-scale route to these compounds for preclinical oncology research, we anticipate this approach could accelerate the synthesis of azaindoles in high-throughput, library-based formats.

PYRROLO [2, 3. B] PYRIDINES WHICH INHIBIT RAF PROTEIN KINASE

-

, (2010/11/18)

Compounds (I) and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, and forms thereof are active on each of BRaf and c-Raf -1 protein kinase, and may also be active on either or both of A-Raf and B-Raf V600E protein kinase. Also described are methods of use thereof to treat diseases and conditions, including melanoma, colorectal cancer, thyroid cancer, ovarian cancer, and biliary tract cancer.

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