INCB 3284 diMesylate

Base Information

• Chemical Name: INCB 3284 diMesylate
• CAS No.: 887401-93-6
• Molecular Formula: 2CH₄O₃S*C₂₆H₃₁F₃N₄O₄
• Molecular Weight: 712.766
• Mol file: 887401-93-6.mol

Synonyms:INCB 3284 dimesylate||INCB3284 dimesylate;INCB3284 dimesylate;cc-408;CS-0958;

Chemical Property of INCB 3284 diMesylate

Chemical Property:

• PSA: 229.29000
• LogP: 4.74900

Purity/Quality:

99%, ^*data from raw suppliers

INCB 3284 dimesylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Dimesylate is a potent, selective, and orally bioavailable hCCR2 antagonist.

Technology Process of INCB 3284 diMesylate

There total 7 articles about INCB 3284 diMesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

methanesulfonic acid (75-75-2,98527-29-8) + INCB3284 (887401-92-5) → N-[2-({(3R)-1-[4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl]pyrrolidin-3-yl}amino)-2-oxoethyl]-3-(trifluoromethyl)benzamide dimethanesulfonate (887401-93-6)

Guidance literature:

In water; 4-methyl-2-pentanone; isopropyl alcohol; at 20 ℃;

Reference yield:

(R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)-ethyl)-3-(trifluoromethyl)benzamide (226249-16-7) + methanesulfonic acid (75-75-2,98527-29-8) + 4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone (708273-57-8) → N-(2-((R)-1-(trans-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide bismethanesulfonate (887401-93-6)

Guidance literature:

(R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)-ethyl)-3-(trifluoromethyl)benzamide; 4-hydroxy-4-(6-methoxy-pyridin-3-yl)-cyclohexanone; With 5% Pt/Al2O3; hydrogen; In dichloromethane; for 18h; under 3102.97 Torr;

methanesulfonic acid; In ethanol; water; ethyl acetate; for 2h;

DOI:10.1021/ml200030q

Reference yield:

(R)-N-(2-(1-benzylpyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide (226228-88-2,226228-42-8) → N-(2-((R)-1-(trans-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide bismethanesulfonate (887401-93-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogen; palladium(II) hydroxide / methanol / 20 °C / 2844.39 Torr

2.1: 5% Pt/Al2O3; hydrogen / dichloromethane / 18 h / 3102.97 Torr

2.2: 2 h

With 5% Pt/Al2O3; hydrogen; palladium(II) hydroxide; In methanol; dichloromethane;

DOI:10.1021/ml200030q

upstream raw materials:

methanesulfonic acid

INCB₃₂₈₄

(R)-N-(2-(1-benzylpyrrolidin-3-ylamino)-2-oxoethyl)-3-(trifluoromethyl)benzamide

(R)-N-(2-oxo-2-(pyrrolidin-3-ylamino)-ethyl)-3-(trifluoromethyl)benzamide

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