(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide

Base Information

• Chemical Name: (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide
• CAS No.: 159857-64-4
• Molecular Formula: C₄₂H₄₆N₄O₄
• Molecular Weight: 670.852
• Mol file: 159857-64-4.mol

Synonyms:(S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide

Chemical Property of (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide

There total 9 articles about (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

Fmoc-Phe-Lys(MMT)-PABOH (159857-63-3) → (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide (159857-64-4)

Guidance literature:

With diethylamine; In N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(97)01158-1

Reference yield:

Fmoc-Lys(Mmt)-OH (159857-60-0) → (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide (159857-64-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / Boc₂O; pyridine

2: Et₂NH / CH₂Cl₂

3: iPr₂NEt / CH₂Cl₂

4: Et₂NH / CH₂Cl₂

With pyridine; di-tert-butyl dicarbonate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(01)00707-7

Reference yield:

4-aminobenzenemethanol (623-04-1) → (S)-2-((S)-2-amino-3-phenyl-propionylamino)-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoic acid (4-hydroxymethyl-phenyl)-amide (159857-64-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 92 percent / Boc₂O; pyridine

2: Et₂NH / CH₂Cl₂

3: iPr₂NEt / CH₂Cl₂

4: Et₂NH / CH₂Cl₂

With pyridine; di-tert-butyl dicarbonate; diethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0960-894X(01)00707-7

upstream raw materials:

Fmoc-Phe-Lys(MMT)-PABOH

4-aminobenzenemethanol

Fmoc-Lys(Mmt)-OH

Fmoc-Lys(Mmt)-aminobenzyl alcohol

Downstream raw materials:

MC-Phe-Lys(MMT)-PAB-OH

Carbonic acid 4-((S)-2-{(S)-2-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexanoylamino]-3-phenyl-propionylamino}-6-{[(4-methoxy-phenyl)-diphenyl-methyl]-amino}-hexanoylamino)-benzyl ester 4-nitro-phenyl ester

O-(2-azidoethyl)-O'-[(N-diglycolyl-2-aminoethyl)-Phe-Lys(MMT)-PAB-OH]heptaethyleneglycol