2-Methylthiophene-3-carboxaldehyde

Base Information

• Chemical Name: 2-Methylthiophene-3-carboxaldehyde
• CAS No.: 84815-20-3
• Molecular Formula: C6H6OS
• Molecular Weight: 126.18
• Hs Code.: 2934999090
• Mol file: 84815-20-3.mol

Synonyms:2-Methylthiophene-3-carboxaldehyde;3-Formyl-2-methylthiophene

Chemical Property of 2-Methylthiophene-3-carboxaldehyde

Chemical Property:

• Vapor Pressure: 0.302mmHg at 25°C
• Boiling Point: 201.8°C at 760 mmHg
• Flash Point: 80.1°C
• PSA: 45.31000
• Density: 1.18g/cm³
• LogP: 1.86900
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-methylthiophene-3-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylthiophene-3-carboxaldehyde

There total 10 articles about 2-Methylthiophene-3-carboxaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-bromo-2-methylthiophene (30319-05-2) + dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) → 2-methyl-3-thiophenecarboxaldehyde (84815-20-3)

Guidance literature:

With triethylsilane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium acetate; In acetonitrile; at 60 ℃; for 16h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.202001328

Reference yield: 81.0%

2-(thiophen-3-yl)-1,3-dioxolane (13250-82-3) + methyl iodide (74-88-4) → 2-methyl-3-thiophenecarboxaldehyde (84815-20-3)

Guidance literature:

2-(thiophen-3-yl)-1,3-dioxolane; methyl iodide; With n-butyllithium; In tetrahydrofuran; hexane; for 1.5h;

methyl iodide; at -70 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h;

Reference yield: 68.0%

3-bromo-2-methylthiophene (30319-05-2) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-methyl-3-thiophenecarboxaldehyde (84815-20-3)

Guidance literature:

3-bromo-2-methylthiophene; With magnesium; lithium chloride; In tetrahydrofuran; Reflux;

N,N-dimethyl-formamide; In tetrahydrofuran; at -5 - 25 ℃; for 2.16667h; Inert atmosphere;

DOI:10.1080/00397911.2011.606391

upstream raw materials:

3-thiophene carboxaldehyde

methyl iodide

3-bromo-2-methylthiophene

N,N-dimethyl-formamide

Downstream raw materials:

2,5-dimethyl-thiophene-3-carbaldehyde

(2-methylthien-3-yl)-1-trityl-imidazol-4-yl-methanol

(2-methyl-thiophen-3-yl)-(1-trityl-1H-imidazol-4-yl)-methanone

2-methyl-3-(2-nitrovinyl)thiophene