Technology Process of 3(4H)-Quinazolineacetic acid, 2-chloro-6-iodo-, ethyl ester
There total 7 articles about 3(4H)-Quinazolineacetic acid, 2-chloro-6-iodo-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 70 percent / H2O; acetic acid / Heating
2: 60.5 g / aq. NaOH / methanol / 1 h / Heating
3: 89 percent / POCl3, N,N-dimethylaniline / 2 h / 150 °C
4: 96 percent / NaBH4 / CHCl3; ethanol / 1.) 0 deg C, 2.) room temperature, 1 h
5: 84 percent / potassium carbonate / butan-2-one / Heating
With
sodium hydroxide; sodium tetrahydroborate; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate;
In
methanol; ethanol; chloroform; water; acetic acid; butanone;
DOI:10.1021/jm00119a014
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / 4-(dimethylamino)pyridine / methanol / 3 h / 60 °C
2: 70 percent / H2O; acetic acid / Heating
3: 60.5 g / aq. NaOH / methanol / 1 h / Heating
4: 89 percent / POCl3, N,N-dimethylaniline / 2 h / 150 °C
5: 96 percent / NaBH4 / CHCl3; ethanol / 1.) 0 deg C, 2.) room temperature, 1 h
6: 84 percent / potassium carbonate / butan-2-one / Heating
With
dmap; sodium hydroxide; sodium tetrahydroborate; potassium carbonate; N,N-dimethyl-aniline; trichlorophosphate;
In
methanol; ethanol; chloroform; water; acetic acid; butanone;
DOI:10.1021/jm00119a014