2-chloro-6-iodo-3,4-dihydroquinazoline

Base Information

• Chemical Name: 2-chloro-6-iodo-3,4-dihydroquinazoline
• CAS No.: 116027-12-4
• Molecular Formula: C₈H₆ClIN₂
• Molecular Weight: 292.507
• Mol file: 116027-12-4.mol

Synonyms:2-chloro-6-iodo-3,4-dihydroquinazoline

Chemical Property of 2-chloro-6-iodo-3,4-dihydroquinazoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-chloro-6-iodo-3,4-dihydroquinazoline

There total 1 articles about 2-chloro-6-iodo-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 2-amino-5-iodobenzoate (77317-55-6) → 2-chloro-6-iodo-3,4-dihydroquinazoline (116027-12-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 70 percent / H₂O; acetic acid / Heating

2: 60.5 g / aq. NaOH / methanol / 1 h / Heating

3: 89 percent / POCl₃, N,N-dimethylaniline / 2 h / 150 °C

4: 96 percent / NaBH₄ / CHCl₃; ethanol / 1.) 0 deg C, 2.) room temperature, 1 h

With sodium hydroxide; sodium tetrahydroborate; N,N-dimethyl-aniline; trichlorophosphate; In methanol; ethanol; chloroform; water; acetic acid;

DOI:10.1021/jm00119a014

Reference yield: 84.0%

ethyl bromoacetate (105-36-2) + 2-chloro-6-iodo-3,4-dihydroquinazoline (116027-12-4) → ethyl (2-chloro-6-iodo-3,4-dihydroquinazolin-3-yl)acetate (116027-13-5)

Guidance literature:

With potassium carbonate; In butanone; Heating;

DOI:10.1021/jm00119a014

Reference yield:

2-chloro-6-iodo-3,4-dihydroquinazoline (116027-12-4) → 7-iodo-1,2,3,5-tetrahydroimidazo<2,1-b>quinazolin-2(1H)-one (108857-18-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / potassium carbonate / butan-2-one / Heating

2: 81 percent / NH₃ / ethane-1,2-diol / 0 - 140 °C

With ammonia; potassium carbonate; In ethylene glycol; butanone;

DOI:10.1021/jm00119a014

upstream raw materials:

methyl 2-amino-5-iodobenzoate

Downstream raw materials:

ethyl (2-chloro-6-iodo-3,4-dihydroquinazolin-3-yl)acetate

7-iodo-1,2,3,5-tetrahydroimidazo<2,1-b>quinazolin-2(1H)-one

Refernces