4-Chloro-5-nitro-2-(trifluoromethyl)pyridine

Base Information

• Chemical Name: 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine
• CAS No.: 438554-45-1
• Molecular Formula: C6H2ClF3N2O2
• Molecular Weight: 226.542
• Hs Code.: 2933399990
• Mol file: 438554-45-1.mol

Synonyms:4-Chloro-5-nitro-2-(trifluoromethyl)pyridine; pyridine, 4-chloro-5-nitro-2-(trifluoromethyl)-; LogP

Chemical Property of 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine

Chemical Property:

• Vapor Pressure: 0.094mmHg at 25°C
• Boiling Point: 231.613°C at 760 mmHg
• PKA: -3.91±0.10(Predicted)
• Flash Point: 93.876°C
• PSA: 58.71000
• Density: 1.619g/cm³
• LogP: 3.18520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-5-nitro-2-(trifluoromethyl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine

There total 2 articles about 4-Chloro-5-nitro-2-(trifluoromethyl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

5-nitro-2-(trifluoromethyl)pyridin-4-ol (438554-44-0) → 4-chloro-5-nitro-2-(trifluoromethyl)pyridine (438554-45-1)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate; at 80 ℃; for 16h;

Reference yield:

4-hydroxy-2-trifluoromethylpyridine (170886-13-2) → 4-chloro-5-nitro-2-(trifluoromethyl)pyridine (438554-45-1)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; sulfuric acid / 48 h / 120 °C / Sealed tube

2: phosphorus pentachloride; trichlorophosphate / 16 h / 80 °C

With phosphorus pentachloride; sulfuric acid; nitric acid; trichlorophosphate;

Reference yield: 100.0%

4-chloro-5-nitro-2-(trifluoromethyl)pyridine (438554-45-1) → 5-nitro-2-(trifluoromethyl)pyridin-4-amine (438564-36-4)

Guidance literature:

With ammonia; In ethanol; at 20 ℃; for 1.5h;

upstream raw materials:

5-nitro-2-(trifluoromethyl)pyridin-4-ol

4-hydroxy-2-trifluoromethylpyridine

Downstream raw materials:

5-nitro-2-(trifluoromethyl)pyridin-4-amine

(S)-5,5-dimethyl-3-((1r,4S)-4-((5-nitro-2-(trifluoromethyl)pyridin-4-yl)amino)cyclohexyl)-4-phenyloxazolidin-2-one

(S)-3-((1r,4S)-4-((5-amino-2-(trifluoromethyl)pyridin-4-yl)amino)cyclohexyl)-5,5-dimethyl-4-phenyloxazolidin-2-one

(S)-5,5-dimethyl-3-((1r,4S)-4-(2-oxo-6-(trifluoromethyl)-2,3-dihydro-1H-imidazo[4,5-c]pyridin-1-yl)cyclohexyl)-4-phenyloxazolidin-2-one

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