1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile

Base Information

• Chemical Name: 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile
• CAS No.: 749928-88-9
• Molecular Formula: C10H7BrFN
• Molecular Weight: 240.075
• Hs Code.: 2926909090
• Mol file: 749928-88-9.mol

Synonyms:1-(4-bromo-2-fluorophenyl)cyclopropanecarbonitrile;Cyclopropanecarbonitrile, 1-(4-bromo-2-fluorophenyl)-;1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile

Chemical Property of 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile

Chemical Property:

• PSA: 23.79000
• LogP: 3.14338
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Very Slightly)

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Bromo-2-fluorophenyl)cyclopropane-1-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile

There total 5 articles about 1-(4-BroMo-2-fluorophenyl)cyclopropane-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(4-bromo-2-fluorophenyl)acetonitrile (114897-91-5) + 1-Bromo-2-chloroethane (107-04-0) → 1-(4-bromo-2-fluorophenyl)cyclopropane-1-carbonitrile (749928-88-9)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide; In water; at 40 ℃; for 9h;

Reference yield: 44.0%

ethylene dibromide (106-93-4) → 1-(4-bromo-2-fluorophenyl)cyclopropane-1-carbonitrile (749928-88-9)

Guidance literature:

(4-bromo-2-fluorophenyl)acetonitrile; With sodium hydride; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); at 0 ℃;

ethylene dibromide; In tetrahydrofuran; DMF (N,N-dimethyl-formamide); for 0.5h;

Reference yield:

(4-bromo-2-fluorophenyl)acetonitrile (114897-91-5) + ethylene dibromide (106-93-4) → 1-(4-bromo-2-fluorophenyl)cyclopropane-1-carbonitrile (749928-88-9)

Guidance literature:

(4-bromo-2-fluorophenyl)acetonitrile; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; for 0.5h; Inert atmosphere; Cooling with ice;

ethylene dibromide; In tetrahydrofuran; N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h; Inert atmosphere; Cooling with ice;

upstream raw materials:

ethylene dibromide

(4-bromo-2-fluorophenyl)acetonitrile

4-bromo-2-fluorobenzyl bromide

1-Bromo-2-chloroethane

Downstream raw materials:

1-(4-bromo-2-fluorophenyl)cyclopropane-1-carboxylic acid

1-(4-bromo-2-fluorophenyl)cyclopropanecarbohydrazide

3-[1-(4-bromo-2-fluorophenyl)cyclopropyl]-8-({[tert-butyl(dimethyl)silyl]oxy}methyl)-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepine

{3-[1-(3-fluorobiphenyl-4-yl)cyclopropyl]-8-methyl-5,6,8,9-tetrahydro[1,2,4]triazolo[4,3-d][1,4]thiazepin-8-yl}methanol

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