1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid
• CAS No.: 936727-93-4
• Molecular Formula: C11H9F3O3
• Molecular Weight: 246.186
• Hs Code.: 2917399590
• Mol file: 936727-93-4.mol

Synonyms:cyclopropanecarboxylic acid, 1-[4-(trifluoromethoxy)phenyl]-

Chemical Property of 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid

Chemical Property:

• Vapor Pressure: 0.000392mmHg at 25°C
• Boiling Point: 304.1°C at 760 mmHg
• Flash Point: 137.7°C
• PSA: 46.53000
• Density: 1.461g/cm³
• LogP: 2.70140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(4-(Trifluoromethoxy)phenyl)cyclopropanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid

There total 4 articles about 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1-((4-trifluoromethoxy)phenyl)cyclopropanecarbonitrile (173859-39-7) → 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid (936727-93-4)

Guidance literature:

With water; lithium hydroxide; at 100 ℃; for 15h;

DOI:10.1021/jm9013696

Reference yield: 73.0%

→ 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid (936727-93-4)

Guidance literature:

Reference yield:

1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbamide (952444-05-2) → 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid (936727-93-4)

Guidance literature:

1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbamide; With sodium hydroxide; water; In methanol; at 78 ℃; for 18h;

With hydrogenchloride; In water; pH=2;

upstream raw materials:

1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbamide

1-((4-trifluoromethoxy)phenyl)cyclopropanecarbonitrile

(4-trifluoromethoxy-phenyl)-acetonitrile

Downstream raw materials:

(3R,4R)-(3-(4,6-dimethylquinolin-2-ylamino)-4-hydroxypyrrolidin-1-yl)-(1-(4-trifluoromethoxyphenyl)cyclopropionyl)methanone

N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

(S)-3-(2,4-dichlorophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoic acid

C₂₂H₂₀Cl₂F₃NO₄