(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

Base Information

Chemical Name:(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate
CAS No.:1239707-77-7
Molecular Formula:C₂₂H₂₁BrF₃NO₄
Molecular Weight:500.312
Hs Code.:

Synonyms:(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

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Chemical Property of (S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

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Technology Process of (S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

There total 4 articles about (S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 936727-93-4
1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid

: 232276-00-5
(S)-ethyl 2-amino-3-(4-bromophenyl)propanoate hydrochloride

: 1239707-77-7
(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile; at 20 ℃; for 1h;
DOI:10.1021/jm300122u

Reference yield:

: 173859-39-7
1-((4-trifluoromethoxy)phenyl)cyclopropanecarbonitrile

: 1239707-77-7
(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / 48 h / 20 - 120 °C

2: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

With water; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In acetonitrile;
DOI:10.1021/jm300122u

Reference yield:

: 62129-39-9,79561-82-3
4-bromo-N-{[(1,1-dimethylethyl)oxy]carbonyl}-L-phenylalanine

: 1239707-77-7
(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 18 h / 90 °C

2: N-ethyl-N,N-diisopropylamine; HATU / acetonitrile / 1 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; HATU; In acetonitrile;
DOI:10.1021/jm300122u