1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile

Base Information

• Chemical Name: 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile
• CAS No.: 173859-39-7
• Molecular Formula: C11H8F3NO
• Molecular Weight: 227.186
• Hs Code.: 2902190000
• Mol file: 173859-39-7.mol

Synonyms:1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile

Chemical Property of 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile

Chemical Property:

• Vapor Pressure: 0.00577mmHg at 25°C
• Boiling Point: 273.3°C at 760 mmHg
• Flash Point: 119.1°C
• PSA: 33.02000
• Density: 1.34g/cm³
• LogP: 3.14038

Purity/Quality:

97% ^*data from raw suppliers

1-(4-(Trifluoromethoxy)phenyl)cyclopropanecarbonitrile ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile

There total 3 articles about 1-(4-(trifluoromethoxy)phenyl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4-trifluoromethoxy-phenyl)-acetonitrile (49561-96-8) + 1-Bromo-2-chloroethane (107-04-0) → 1-((4-trifluoromethoxy)phenyl)cyclopropanecarbonitrile (173859-39-7)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; at 50 ℃;

DOI:10.1021/jm9013696

Reference yield: 98.3%

→ 1-((4-trifluoromethoxy)phenyl)cyclopropanecarbonitrile (173859-39-7)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; In water; at 50 ℃; for 16h; Inert atmosphere;

Reference yield:

(4-trifluoromethoxy-phenyl)-acetonitrile (49561-96-8) + ethylene dibromide (106-93-4) → 1-((4-trifluoromethoxy)phenyl)cyclopropanecarbonitrile (173859-39-7)

Guidance literature:

(4-trifluoromethoxy-phenyl)-acetonitrile; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.666667h; Cooling with ice;

ethylene dibromide; In tetrahydrofuran; mineral oil; at 20 ℃; for 18h; Cooling with ice;

DOI:10.1021/jm300122u

upstream raw materials:

(4-trifluoromethoxy-phenyl)-acetonitrile

1-Bromo-2-chloroethane

ethylene dibromide

Downstream raw materials:

1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxylic acid

N-{(1S)-2-(3-amino-8-azabicyclo[3.2.1]oct-8-yl)-1-[(2,4-dichlorophenyl)methyl]-2-oxoethyl}-1-{4-[(trifluoromethyl)oxy]phenyl}cyclopropanecarboxamide

(S)-ethyl 3-(4-bromophenyl)-2-(1-(4-(trifluoromethoxy)phenyl)cyclopropanecarboxamido)propanoate

C₂₂H₂₀Cl₂F₃NO₄