5(R)-5-{(tert-butyldimethylsilyloxy)methyl}pyrrolidin-2-one

Base Information

Chemical Name:5(R)-5-{(tert-butyldimethylsilyloxy)methyl}pyrrolidin-2-one
CAS No.:100548-49-0
Molecular Formula:C₁₁H₂₃NO₂Si
Molecular Weight:229.395
Hs Code.:
Mol file:100548-49-0.mol

Synonyms:D-O-TBDMS-PYROGLUTAMINOL;(R)-5-((tert-butyldiMethylsilyloxy)Methyl)pyrrolidin-2-one;(R)-5-(t-butyldimethylsiloxymethyl)-2-pyrrolidinone;(5R)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolidin-2-one;(2R)-2-[[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]METHYL]-5-OXO-1-PYRROLIDINE;(R)-5-(tert-butyldimethylsilanyloxymethyl)pyrrolidin-2-one;5R-(tert-butyl-dimethylsylanyloxymethyl)pyrrolidin-2-one;(5R)-5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyrrolidine-2-one;

Suppliers and Price of 5(R)-5-{(tert-butyldimethylsilyloxy)methyl}pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 6 raw suppliers

Chemical Property of 5(R)-5-{(tert-butyldimethylsilyloxy)methyl}pyrrolidin-2-one

Chemical Property:

PSA：41.82000
LogP:2.56270

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5(R)-5-{(tert-butyldimethylsilyloxy)methyl}pyrrolidin-2-one

There total 9 articles about 5(R)-5-{(tert-butyldimethylsilyloxy)methyl}pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 66673-40-3
(R)-5-hydroxymethylpyrrolidin-2-one

: 18162-48-6
tert-butyldimethylsilyl chloride

: 128899-30-9,100548-49-0,106191-02-0
(R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one

Guidance literature:: With 1H-imidazole; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.tet.2013.02.014

Reference yield: 24.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 4042-36-8
D-pyrrolidone-5-carboxylic acid

: 128899-30-9,100548-49-0,106191-02-0
(R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one

Guidance literature:: D-pyrrolidone-5-carboxylic acid; With thionyl chloride; In methanol; at 0 - 20 ℃; for 1h;

With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 16h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 16h;