96914-00-0

Usage

InChI:InChI=1/C5H7NO2/c7-3-4-1-2-5(8)6-4/h3-4H,1-2H2,(H,6,8)/t4-/m0/s1

Upstream product

• 185303-87-1 tert-butyl (S)-2-formyl-5-oxopyrrolidine-1-carboxylate 
• 98-79-3 L-Pyroglutamic acid 
• 1298024-11-9 (5S)-pyrrolidin-2-one-5-carbothioic acid ethyl ester 
• 1298023-90-1 (5S)-N-(tert-butyloxycarbonyl)pyrrolidin-2-one-5-carbothioic acid ethyl ester 
• 4042-36-8 D-pyrrolidone-5-carboxylic acid 
• 62400-75-3 pyroglutamol 

Downstream Products

• 128899-30-9 (R)-5-(((tert-butyldimethylsilyl)oxy)methyl)pyrrolidin-2-one 

Relevant academic research and scientific papers

AMIDE DERIVATIVE INHIBITOR AND PREPARATION METHOD AND APPLICATION THEREOF

An amide derivative inhibitor and a preparation method and an application thereof. Specifically relating to the compound shown in general formula (I), a preparation method for same, a pharmaceutical composition comprising said compound, and an application of same as an ASK inhibitor for the treatment of neurodegenerative disease, cardiovascular disease, inflammation, autoimmune and metabolic disease, each of the substituents in the general formula (I) being as defined in the description.

A kind of IDO inhibitor and use thereof

The embodiment of the invention provides general formula (I) compound or its pharmaceutically acceptable salts, stereoisomers, a tautomeric form each other, polymorphs, solvate, prodrug, metabolite or isotope derivatives, wherein the substituents R1

Quinoline-based compound and selective androgen receptor agonist comprising the same

Provided are a novel quinoline-based compound, a pharmaceutical composition containing the quinoline-based compound, and a method for producing the quinoline-based compound. The quinoline-based compound acts on an androgen receptor to increase activities of the androgen receptor, and thus can be favorably used as an agent for treating and preventing diseases or conditions, in which the increased activities of the androgen can lead to improvement of symptoms or the responsiveness to treatment, for example, various hormone-related diseases of the male or female, muscle-wasting disease, osteoporosis, and the like.COPYRIGHT KIPO 2016

Halomethyl derivatives of gamma-aminobutyric acid and related compounds

Novel compounds of the following general formula are useful pharmacological agents: STR1 wherein Y is FCH2 - or F2 CH-; R1 is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, -NR10 R11 wherein each of R10 and R11 is hydrogen or a straight or branched alkyl group of from 1 to 4 carbon atoms or STR2 wherein R12 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R2 is hydrogen, alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or STR3 wherein R8 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; and n is the integer 2 or 3; pharmaceutically acceptable salts and individual optical isomers thereof.