Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

Base Information

Chemical Name:Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate
CAS No.:215808-73-4
Molecular Formula:C9H11NO5
Molecular Weight:213.18734
Hs Code.:2934999090
DSSTox Substance ID:DTXSID20445378
Nikkaji Number:J1.050.389B
Wikidata:Q82263750
Mol file:215808-73-4.mol

Synonyms:215808-73-4;Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate;methyl 5-(2-methoxy-2-oxoethyl)-2-methyl-1,3-oxazole-4-carboxylate;SCHEMBL2720833;DTXSID20445378;YSOBBXNPVDOCNQ-UHFFFAOYSA-N;Methyl5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate;AKOS015919503;FT-0703650;A879016;2-Methyl-5-(methoxycarbonylmethyl)-4-oxazolecarboxylic acid methyl ester

Suppliers and Price of Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate 95+%
1g
$ 772.00

Chemenu
Methyl5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate 95%
1g
$ 729.00

American Custom Chemicals Corporation
METHYL-5-(2-METHOXY-2-OXOETHYL)-2-METHYLOXAZOLE-4-CARBOXYLATE 95.00%
5MG
$ 503.25

Total 11 raw suppliers

Chemical Property of Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

Chemical Property:

PSA：78.63000
LogP:0.48510
Storage Temp.:2-8°C
XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:213.06372245
Heavy Atom Count:15
Complexity:255

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=NC(=C(O1)CC(=O)OC)C(=O)OC

Technology Process of Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

There total 4 articles about Methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 188657-38-7
dimethyl 2-acetamido-3-oxopentanedioate

: 215808-73-4
methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

Guidance literature:: dimethyl 2-acetamido-3-oxopentanedioate; With thionyl chloride; In chloroform; at 0 ℃; Reflux;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃;

Reference yield:

: 868-09-7
2-hydroxyimino-3-oxo-pentanedioic acid dimethyl ester

: 215808-73-4
methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Zinc dust, acetic acid, 2.) H₂O / 1.) below 40 deg C, 10 min, 2.) room temperature, 2 h

2: SOCl₂ / CHCl₃ / Heating

With thionyl chloride; water; acetic acid; zinc; In chloroform;
DOI:10.1021/jo980505w

Reference yield:

: 1830-54-2
3-oxopentanedioic acid dimethyl ester

: 215808-73-4
methyl 5-(2-methoxy-2-oxoethyl)-2-methyloxazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium nitrite; acetic acid / water / 0 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / 3 h / 20 °C

3.1: thionyl chloride / chloroform / 0 °C / Reflux

3.2: 0 °C

With thionyl chloride; hydrogen; acetic acid; sodium nitrite; palladium 10% on activated carbon; In chloroform; water;