3,4-Diamino-6-trifluoromethylpyridine

Base Information

• Chemical Name: 3,4-Diamino-6-trifluoromethylpyridine
• CAS No.: 438564-37-5
• Molecular Formula: C6H6F3N3
• Molecular Weight: 177.1271
• Mol file: 438564-37-5.mol

Synonyms:3,4-pyridinediamine, 6-(trifluoromethyl)-; 6-(Trifluoromethyl)pyridine-3,4-diamine

Chemical Property of 3,4-Diamino-6-trifluoromethylpyridine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 324.161°C at 760 mmHg
• PKA: 4.59±0.50(Predicted)
• Flash Point: 149.848°C
• PSA: 64.93000
• Density: 1.467g/cm³
• LogP: 2.42720
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6-(Trifluoromethyl)pyridine-3,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,4-Diamino-6-trifluoromethylpyridine

There total 5 articles about 3,4-Diamino-6-trifluoromethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-nitro-2-(trifluoromethyl)pyridin-4-amine (438564-36-4) → 6-(trifluoromethyl)pyridine-3,4-diamine (438564-37-5)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; ethyl acetate; at 20 ℃; for 27h;

Reference yield:

5-nitro-2-(trifluoromethyl)pyridin-4-ol (438554-44-0) → 6-(trifluoromethyl)pyridine-3,4-diamine (438564-37-5)

Guidance literature:

Multi-step reaction with 3 steps

1: phosphorus pentachloride; trichlorophosphate / 16 h / 80 °C

2: ammonia / ethanol / 2.25 h / -78 - 20 °C / Sealed tube

3: palladium 10% on activated carbon; hydrogen / methanol; water; ethyl acetate / 5 h / 20 °C / 760.05 Torr

With phosphorus pentachloride; palladium 10% on activated carbon; ammonia; hydrogen; trichlorophosphate; In methanol; ethanol; water; ethyl acetate;

Reference yield:

4-chloro-5-nitro-2-(trifluoromethyl)pyridine (438554-45-1) → 6-(trifluoromethyl)pyridine-3,4-diamine (438564-37-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonia / ethanol / 2.25 h / -78 - 20 °C / Sealed tube

2: palladium 10% on activated carbon; hydrogen / methanol; water; ethyl acetate / 5 h / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; ammonia; hydrogen; In methanol; ethanol; water; ethyl acetate;

upstream raw materials:

5-nitro-2-(trifluoromethyl)pyridin-4-amine

5-nitro-2-(trifluoromethyl)pyridin-4-ol

4-chloro-5-nitro-2-(trifluoromethyl)pyridine

4-hydroxy-2-trifluoromethylpyridine

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