2-bromo-1-chloro-3-methoxybenzene

Base Information

• Chemical Name: 2-bromo-1-chloro-3-methoxybenzene
• CAS No.: 174913-08-7
• Molecular Formula: C7H6BrClO
• Molecular Weight: 221.48
• Hs Code.: 2909303890
• Mol file: 174913-08-7.mol

Synonyms:Anisole, 2-bromo-3-chloro- (3CI);Benzene, 2-bromo-1-chloro-3-methoxy-;2-Bromo-3-chloroanisole;

Chemical Property of 2-bromo-1-chloro-3-methoxybenzene

Chemical Property:

• Melting Point: 50 °C
• Boiling Point: 246.5±20.0 °C(Predicted)
• PSA: 9.23000
• Density: 1.564±0.06 g/cm3(Predicted)
• LogP: 3.11110

Purity/Quality:

98.5% ^*data from raw suppliers

2-Bromo-1-chloro-3-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-bromo-1-chloro-3-methoxybenzene

There total 5 articles about 2-bromo-1-chloro-3-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.5%

1-chloro-3-methoxy-benzene (2845-89-8) → 4-bromo-3-chloroanisole (50638-46-5) + 2-bromo-3-chloro-anisole (174913-08-7)

Guidance literature:

With (CH₃)4Br; In liquid sulphur dioxide; at -23 ℃;

DOI:10.1002/hlca.19830660410

Reference yield:

3-monochlorophenol (108-43-0) → 2-bromo-3-chloro-anisole (174913-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: fuming sulfuric acid / Reaktion ueber mehrere Stufen

2: aqueous NaOH

With sodium hydroxide; sulfuric acid;

DOI:10.1039/jr9300001419

Reference yield:

3-chloro-2-nitroanisole (5472-99-1) → 2-bromo-3-chloro-anisole (174913-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid

2: Diazotization_.Behandlung des Diazoniumsalzes mit Kupfer(I)-bromid

With iron; acetic acid;

DOI:10.1557/JMR.2000.0198

upstream raw materials:

6-chloro-o-anisidine

2-bromo-3-chlorophenol

dimethyl sulfate

1-chloro-3-methoxy-benzene