2-Chloro-6-methoxyaniline

Base Information

• Chemical Name: 2-Chloro-6-methoxyaniline
• CAS No.: 158966-62-2
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.6
• Hs Code.: 2922299090
• European Community (EC) Number: 890-269-8
• DSSTox Substance ID: DTXSID50438475
• Nikkaji Number: J160.870C
• Wikidata: Q82254233
• Mol file: 158966-62-2.mol

Synonyms:2-Chloro-6-methoxyaniline;158966-62-2;2-chloro-6-methoxyphenylamine;Benzenamine, 2-chloro-6-methoxy-;2-amino-3-chloroanisole;MFCD14455911;2-chloro-6-methoxybenzenamine;SCHEMBL101875;DTXSID50438475;SEZKSJHQUIRBCN-UHFFFAOYSA-N;CL9146;AKOS006221152;AM83274;CS-W019133;DS-4384;SB76190;SY114665;EN300-42580;AN-584/43422706

Chemical Property of 2-Chloro-6-methoxyaniline

Chemical Property:

• Boiling Point: 246 °C
• PKA: 2.60±0.10(Predicted)
• PSA: 35.25000
• Density: 1.234±0.06 g/cm3(Predicted)
• LogP: 2.51200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 157.0294416
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-6-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=CC=C1)Cl)N

Technology Process of 2-Chloro-6-methoxyaniline

There total 13 articles about 2-Chloro-6-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

N-(2-chloro-6-methoxyphenyl)-2,2-dimethylpropionamide (934537-35-6) → 6-chloro-o-anisidine (158966-62-2)

Guidance literature:

N-(2-chloro-6-methoxyphenyl)-2,2-dimethylpropionamide; With hydrogenchloride; In water; acetic acid; at 75 ℃; for 72h;

With ammonia; In water;

Reference yield: 87.0%

→ 6-chloro-o-anisidine (158966-62-2)

Guidance literature:

Reference yield: 58.0%

3-chloro-2-nitroanisole (5472-99-1) → 6-chloro-o-anisidine (158966-62-2)

Guidance literature:

With sodium dithionite;

DOI:10.7164/antibiotics.47.602

upstream raw materials:

3-chloro-2-nitroanisole

2-bromoanisole

ethyl 6-chloro-2-methoxycarbanilate

acetic acid

Downstream raw materials:

2-Chlor-6-methoxybenzoesaeurenitril

2-bromo-3-chloro-anisole

1-chloro-2-iodo-3-methoxybenzene

2-chloro-4-iodo-6-methoxy-aniline