ethyl 2-Methyl-2-(pyridin-3-yl)propanoate

Base Information

• Chemical Name: ethyl 2-Methyl-2-(pyridin-3-yl)propanoate
• CAS No.: 120690-70-2
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.246
• Mol file: 120690-70-2.mol

Synonyms:ethyl 2-methyl-2-pyridin-3-yl-propanoate;ethyl 2-methyl-2-(pyridin-3-yl)propanoate;2-Methyl-2-pyridin-3-yl-propionic acid ethyl ester;ethyl 2-methyl-2-(3-pyridyl)propionate;

Chemical Property of ethyl 2-Methyl-2-(pyridin-3-yl)propanoate

Chemical Property:

• PSA: 39.19000
• LogP: 1.92230

Purity/Quality:

97% ^*data from raw suppliers

Ethyl2-Methyl-2-(pyridin-3-yl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-Methyl-2-(pyridin-3-yl)propanoate

There total 3 articles about ethyl 2-Methyl-2-(pyridin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

pyridin-3-yl-acetic acid ethyl ester (39931-77-6) + aqueous NH4 Cl + potassium hexamethyldisilazane → ethyl 2-methyl-2-(pyridin-3-yl)propionate (120690-70-2)

Guidance literature:

With methyl iodide; In tetrahydrofuran;

Reference yield: 83.0%

pyridin-3-yl-acetic acid ethyl ester (39931-77-6) + methyl iodide (74-88-4) → ethyl 2-methyl-2-(pyridin-3-yl)propionate (120690-70-2)

Guidance literature:

potassium hexamethylsilazane; at 20 ℃; for 12h;

DOI:10.1016/S0040-4039(01)01322-3

Reference yield:

pyridin-3-yl-acetic acid ethyl ester (39931-77-6) + potassium t-tuboxide + methyl iodide (74-88-4) → ethyl 2-methyl-2-(pyridin-3-yl)propionate (120690-70-2)

Guidance literature:

In tetrahydrofuran;

upstream raw materials:

pyridin-3-yl-acetic acid ethyl ester

methyl iodide

Downstream raw materials:

2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-3-[1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-pyrrolo[2,3-b]pyridine-1-carboxylic acid tert-butyl ester

(S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one

(S)-1-(2-azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-hydroxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-1-(tert-butoxycarbonyl)-pyrrolo[2,3-b]-pyridin-5-yl]-2-methylpropan-1-one

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