2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

Base Information

Chemical Name:2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid
CAS No.:1265322-67-5
Molecular Formula:C₂₉H₂₉F₃N₄O₅
Molecular Weight:570.568
Hs Code.:

Synonyms:2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

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Chemical Property of 2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

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Technology Process of 2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

There total 9 articles about 2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1265322-67-5
2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C

2: 1,1-dichloroethane / 20 - 70 °C

3: 2,2,6,6-tetramethyl-piperidine-N-oxyl; disodium hydrogenphosphate; sodium chlorite; sodium dihydrogenphosphate / acetonitrile; water / 20 - 35 °C

4: pyridine; trifluoro-[1,3,5]triazine / 20 °C

5: N-ethyl-N,N-diisopropylamine / acetonitrile / 3 h / 62 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

7: caesium carbonate / ethanol / 80 °C

8: hydrogenchloride / 1,4-dioxane / 72 h / 60 °C

With pyridine; hydrogenchloride; 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium chlorite; disodium hydrogenphosphate; sodium dihydrogenphosphate; N-chloro-succinimide; trifluoro-[1,3,5]triazine; caesium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; 1,1-dichloroethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: C₃₁H₃₃F₃N₄O₅

: 1265322-67-5
2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 60 ℃; for 72h;

Reference yield:

: 120690-70-2
ethyl 2-methyl-2-(pyridin-3-yl)propionate

: 1265322-67-5
2-(1-((S)-2-hydroxy-2-(4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)piperidin-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; acetic acid / platinum(IV) oxide / 72 h / 2585.81 Torr

2: caesium carbonate / ethanol / 80 °C

3: hydrogenchloride / 1,4-dioxane / 72 h / 60 °C

With hydrogenchloride; hydrogen; caesium carbonate; acetic acid; platinum(IV) oxide; In 1,4-dioxane; ethanol;