Ethyl 2,5-dimethoxybenzoylformate

Base Information

• Chemical Name: Ethyl 2,5-dimethoxybenzoylformate
• CAS No.: 911047-42-2
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Hs Code.: 2918990090
• Mol file: 911047-42-2.mol

Synonyms:ETHYL 2,5-DIMETHOXYBENZOYLFORMATE

Chemical Property of Ethyl 2,5-dimethoxybenzoylformate

Chemical Property:

• Vapor Pressure: 1.53E-05mmHg at 25°C
• Boiling Point: 365.8°C at 760 mmHg
• Flash Point: 162.3°C
• PSA: 61.83000
• Density: 1.159g/cm³
• LogP: 1.44960

Purity/Quality:

97% ^*data from raw suppliers

(2,5-Dimethoxyphenyl)oxoaceticacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2,5-dimethoxybenzoylformate

There total 2 articles about Ethyl 2,5-dimethoxybenzoylformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Ethyl oxalyl chloride (4755-77-5) + 1,4-dimethoxybezene (150-78-7) → 2,5-dimethoxyphenylglyoxylic acid ethyl ester (911047-42-2)

Guidance literature:

With aluminium trichloride; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1055/s-2006-942404

Reference yield:

ethanol (64-17-5) + 2-bromo-2',5'-dimethoxyacetophenone (1204-21-3) → 2,5-dimethoxyphenylglyoxylic acid ethyl ester (911047-42-2)

Guidance literature:

With selenium(IV) oxide;

Reference yield: 77.0%

2,5-dimethoxyphenylglyoxylic acid ethyl ester (911047-42-2) → ethyl hydroxy(2,5-dimethoxyphenyl)acetate (56979-61-4)

Guidance literature:

With sodium tetrahydroborate; In ethanol; at -30 ℃; for 0.25h;

DOI:10.1055/s-2006-942404

upstream raw materials:

Ethyl oxalyl chloride

1,4-dimethoxybezene

ethanol

2-bromo-2',5'-dimethoxyacetophenone

Downstream raw materials:

ethyl hydroxy(2,5-dimethoxyphenyl)acetate

bromo 2,5-dimethoxyphenylacetic acid ethyl ester

(rac)-2-(2,5-dimethoxyphenyl)-2-hydroxyacetic acid

Refernces

• 1、 Ianni, Alen,Waldvogel, Siegfried R.. "Reliable and versatile synthesis of 2-aryl-substituted cinnamic acid esters". . p. 2103 - 2112. Retrieved 2008/02/02.