2,6-Diiodo-3-methoxypyridine

Base Information

• Chemical Name: 2,6-Diiodo-3-methoxypyridine
• CAS No.: 437709-98-3
• Molecular Formula: C6H5I2NO
• Molecular Weight: 360.921
• Hs Code.: 2933399990
• DSSTox Substance ID: DTXSID30471542
• Nikkaji Number: J1.754.091B
• Wikidata: Q82300076
• Mol file: 437709-98-3.mol

Synonyms:2,6-Diiodo-3-methoxypyridine;437709-98-3;YSZC3646;DTXSID30471542;MFCD11857683;AKOS005073383;LD-0049;2,6-Diiodo-3-methoxypyridine, AldrichCPR;CS-0323161;FT-0738326;E79671;J-507489

Chemical Property of 2,6-Diiodo-3-methoxypyridine

Chemical Property:

• PSA: 22.12000
• LogP: 2.29940
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 360.84606
• Heavy Atom Count: 10
• Complexity: 112

Purity/Quality:

98%min ^*data from raw suppliers

2,6-Diiodo-3-methoxypyridine Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(N=C(C=C1)I)I

Technology Process of 2,6-Diiodo-3-methoxypyridine

There total 3 articles about 2,6-Diiodo-3-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

2,6-diiodo-3-hydroxypyridine (14764-90-0) + methyl iodide (74-88-4) → 2,6-diiodo-3-methoxypyridine (437709-98-3)

Guidance literature:

2,6-diiodo-3-hydroxypyridine; With sodium methylate; In N,N-dimethyl-formamide; for 0.5h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Further stages.;

DOI:10.1021/jo010913r

Reference yield:

diazomethane (186581-53-3,908094-01-9,334-88-3) + 2,6-diiodo-3-hydroxypyridine (14764-90-0) → 2,6-diiodo-3-methoxypyridine (437709-98-3)

Guidance literature:

With methanol; diethyl ether;

DOI:10.1021/ja01207a049

Reference yield:

2,6-diiodo-3-hydroxypyridine (14764-90-0) + dimethyl sulfate (77-78-1) → 2,6-diiodo-3-methoxypyridine (437709-98-3)

Guidance literature:

With sodium hydroxide; water;

upstream raw materials:

diazomethane

2,6-diiodo-3-hydroxypyridine

dimethyl sulfate

methyl iodide