2,6-Diiodopyridin-3-ol

Base Information

• Chemical Name: 2,6-Diiodopyridin-3-ol
• CAS No.: 14764-90-0
• Molecular Formula: C5H3 I2 N O
• Molecular Weight: 346.894
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID30382806
• Nikkaji Number: J323.946B
• Wikidata: Q82174251
• Mol file: 14764-90-0.mol

Synonyms:2,6-diiodopyridin-3-ol;14764-90-0;2,6-diiodo-3-pyridinol;2,6-Diiodo-3-hydroxypyridine;SCHEMBL6707376;2,6-diiodo-3-hydroxy-pyridine;DTXSID30382806;ZDOQSPXMJKWUIV-UHFFFAOYSA-N;MFCD03265756;AKOS005073106;KD-0076;MethylD-2-(4-fluorophenyl)glycinateHCl;CS-0320913;FT-0742032;J-507491

Chemical Property of 2,6-Diiodopyridin-3-ol

Chemical Property:

• Melting Point: 198-199 °C
• Boiling Point: 391.4±42.0 °C(Predicted)
• PKA: 4.32±0.10(Predicted)
• PSA: 33.12000
• Density: 2.769±0.06 g/cm3(Predicted)
• LogP: 1.99640
• Storage Temp.: 2-8°C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 346.83041
• Heavy Atom Count: 9
• Complexity: 101

Purity/Quality:

98%min ^*data from raw suppliers

2,6-diiodo-3-pyridinol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1O)I)I

Technology Process of 2,6-Diiodopyridin-3-ol

There total 8 articles about 2,6-Diiodopyridin-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-HYDROXYPYRIDINE (109-00-2) → 2-iodo-3-hydroxypyridine (40263-57-8) + 2,6-diiodo-3-hydroxypyridine (14764-90-0) + 3-hydroxy-2,4,6-triiodopyridine (67868-14-8)

Guidance literature:

With iodine; sodium carbonate; In water; at 20 ℃; for 0.5h; Yields of byproduct given;

DOI:10.1055/s-1990-26918

Reference yield: 72.0%

3-HYDROXYPYRIDINE (109-00-2) → 2,6-diiodo-3-hydroxypyridine (14764-90-0)

Guidance literature:

With iodine; potassium carbonate; In water; for 2h;

DOI:10.1002/chem.201000315

Reference yield:

3-HYDROXYPYRIDINE (109-00-2) → 2-iodo-3-hydroxypyridine (40263-57-8) + 2,6-diiodo-3-hydroxypyridine (14764-90-0) + 5-hydroxy-2-iodopyridine (129034-38-4)

Guidance literature:

With iodine; potassium carbonate; Yield given. Multistep reaction. Yields of byproduct given; 1) DMF, 60 deg C; 2) DMF;

DOI:10.1021/jo970062g

upstream raw materials:

3-HYDROXYPYRIDINE

5-hydroxypicolinic acid

3-hydroxypyridine-2-carboxylic acid

water

Downstream raw materials:

2,6-diiodo-3-methoxypyridine

2,6-diiodo-N,N-diisopropylpyridine-3-carbamate

N,N-diethyl-2,6-diodopyridine-3-carbamate

4-chloro-2,6-diiodo-N,N-diisopropylpyridine-3-carbamate

Refernces

• 1、 -. "RING-FUSED MORPHOLINE DERIVATIVE HAVING PI3K-INHIBITING ACTIVITY". Page/Page column 33. . Retrieved 2011/07/30.
• 2、 Sheldrake, Peter W.,Powling, Laurence C.,Slaich, Pritpal K.. "Preparation of 5-Hydroxy-2-iodopyridine: A Refutation of Earlier Reports". . p. 3008 - 3009. Retrieved 2007/10/03.