5,6-Dimethoxynicotinonitrile

Base Information

• Chemical Name: 5,6-Dimethoxynicotinonitrile
• CAS No.: 1112851-31-6
• Molecular Formula: C8H8N2O2
• Molecular Weight: 164.16
• Hs Code.: 2933399090
• Mol file: 1112851-31-6.mol

Synonyms:5,6-Dimethoxynicotinonitrile;5,6-dimethoxynicotinic acid nitrile;

Chemical Property of 5,6-Dimethoxynicotinonitrile

Chemical Property:

• PSA: 55.14000
• LogP: 0.97048

Purity/Quality:

98%min ^*data from raw suppliers

5,6-Dimethoxynicotinonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-Dimethoxynicotinonitrile

There total 2 articles about 5,6-Dimethoxynicotinonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

5-bromo-2,3-dimethoxypyridine (52605-98-8) + copper(l) cyanide → 5,6-dimethoxypyridine-3-carbonitrile (1112851-31-6)

Guidance literature:

In N,N-dimethyl-formamide; at 180 ℃; for 0.666667h; Inert atmosphere; Microwave irradiation;

DOI:10.1002/cmdc.201300447

Reference yield:

2,3-dimethoxypyridine (52605-97-7) → 5,6-dimethoxypyridine-3-carbonitrile (1112851-31-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; bromine / water; dichloromethane / 2 h / 0 - 25 °C

2: N,N-dimethyl-formamide / 0.67 h / 180 °C / Inert atmosphere; Microwave irradiation

With bromine; sodium hydrogencarbonate; In dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201300447

Reference yield: 73.0%

5,6-dimethoxypyridine-3-carbonitrile (1112851-31-6) → 5,6-dimethoxynicotinic acid (76470-34-3)

Guidance literature:

With sodium hydroxide; In ethanol; at 90 ℃; for 16h;

upstream raw materials:

5-bromo-2,3-dimethoxypyridine

2,3-dimethoxypyridine

Downstream raw materials:

5,6-dimethoxynicotinic acid

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