2-Bromo-3-iodo-5-nitropyridine

Base Information

• Chemical Name: 2-Bromo-3-iodo-5-nitropyridine
• CAS No.: 25391-61-1
• Molecular Formula: C5H2BrIN2O2
• Molecular Weight: 328.89005
• Hs Code.: 2933399090
• Mol file: 25391-61-1.mol

Synonyms:2-BROMO-3-IODO-5-NITROPYRIDINE

Chemical Property of 2-Bromo-3-iodo-5-nitropyridine

Chemical Property:

• PSA: 58.71000
• LogP: 2.88010

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-3-iodo-5-nitropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3-iodo-5-nitropyridine

There total 1 articles about 2-Bromo-3-iodo-5-nitropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

2-hydroxy-3-iodo-5-nitropyridine (25391-58-6) → 2-bromo-3-iodo-5-nitropyridine (25391-61-1)

Guidance literature:

With phosphorus(V) oxybromide; In quinoline; toluene; at 90 - 100 ℃;

DOI:10.1021/jm030432v

Reference yield: 74.0%

2-bromo-3-iodo-5-nitropyridine (25391-61-1) → 5-amino-2-bromo-3-iodopyridine (697300-68-8)

Guidance literature:

With iron; acetic acid; at 70 - 72 ℃;

DOI:10.1021/jm030432v

Reference yield:

2-bromo-3-iodo-5-nitropyridine (25391-61-1) → 2-bromo-5-hydroxy-3-iodopyridine (697300-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 74 percent / iron powder; aq. acetic acid / 70 - 72 °C

2.1: HBF₄; NaNO₂ / H₂O / 0.33 h / 0 °C

2.2: 1 h / 70 - 85 °C

3.1: 1.44 g / KOH / propan-2-ol / 1 h

With potassium hydroxide; tetrafluoroboric acid; iron; acetic acid; sodium nitrite; In water; isopropyl alcohol;

DOI:10.1021/jm030432v

upstream raw materials:

2-hydroxy-3-iodo-5-nitropyridine

Downstream raw materials:

5-amino-2-bromo-3-iodopyridine

2-bromo-5-hydroxy-3-iodopyridine