Methyl 6-chloro-5-methylpicolinate

Base Information

• Chemical Name: Methyl 6-chloro-5-methylpicolinate
• CAS No.: 178421-22-2
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID00592798
• Wikidata: Q82487104
• Mol file: 178421-22-2.mol

Synonyms:Methyl 6-chloro-5-methylpicolinate;178421-22-2;methyl 6-chloro-5-methylpyridine-2-carboxylate;2-Pyridinecarboxylic acid, 6-chloro-5-methyl-, methyl ester;MFCD18255502;Methyl6-chloro-5-methylpicolinate;SCHEMBL2255434;6-chloro-5-methyl-pyridine-2-carboxylic acid methyl ester;DTXSID00592798;AMIHCSRDGRJMTO-UHFFFAOYSA-N;AKOS015998905;CS-W022878;GS-3772;SY110904;DB-360847;methyl 6-chloro-5-methyl-2-pyridinecarboxylate;A881394

Chemical Property of Methyl 6-chloro-5-methylpicolinate

Chemical Property:

• Boiling Point: 298.13 °C at 760 mmHg
• PKA: -0.74±0.10(Predicted)
• Flash Point: 134.104 °C
• PSA: 39.19000
• Density: 1.248 g/cm³
• LogP: 1.83000
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 185.0243562
• Heavy Atom Count: 12
• Complexity: 174

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methyl6-chloro-5-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(N=C(C=C1)C(=O)OC)Cl

Technology Process of Methyl 6-chloro-5-methylpicolinate

There total 6 articles about Methyl 6-chloro-5-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

→ methyl 6-chloro-5-methylpyridine-2-carboxylate (178421-22-2)

Guidance literature:

Reference yield: 58.3%

methyl 5-methyl-2-pyridinecarboxylate N-oxide (401792-77-6) → methyl 4-chloro-5-methylpyridine-2-carboxylate (1104455-41-5) + methyl 6-chloro-5-methylpyridine-2-carboxylate (178421-22-2)

Guidance literature:

methyl 5-methyl-2-pyridinecarboxylate N-oxide; With trichlorophosphate; In chloroform; at 80 ℃; for 0.0833333h;

With potassium carbonate; In chloroform; water; pH=7;

Reference yield: 57.0%

methyl 5-methyl-2-pyridinecarboxylate N-oxide (401792-77-6) → methyl 6-chloro-5-methylpyridine-2-carboxylate (178421-22-2)

Guidance literature:

With trichlorophosphate; In chloroform; at 80 ℃;

upstream raw materials:

methanol

4,6-dichloro-1-methyl-2-oxa-5-azabicyclo<2.2.2>oct-5-en-3-one

methyl 5-methyl-2-pyridinecarboxylate N-oxide

methyl 5-methylpyridine-2-carboxylate

Refernces

• 1、 -. "PICOLINAMIDE AND PYRIMIDINE-4-CARBOXAMIDE COMPOUNDS, PROCESS FOR PREPARING AND PHAMACEUTICAL COMPOSITION COMPRISING THE SAME". Page/Page column 85-86. . Retrieved 2011/11/30.
• 2、 -. "2,4-DIAMINO-PYRIMIDINE DERIVATIVES". Page/Page column 62-63. . Retrieved 2009/03/07.