Methyl 4-chloro-5-methylpicolinate

Base Information

• Chemical Name: Methyl 4-chloro-5-methylpicolinate
• CAS No.: 1104455-41-5
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Hs Code.: 2933399090
• Mol file: 1104455-41-5.mol

Synonyms:4-Chloro-5-methylpyridine-2-carboxylic acid methyl ester;

Chemical Property of Methyl 4-chloro-5-methylpicolinate

Chemical Property:

• Boiling Point: 287.703 °C at 760 mmHg
• Flash Point: 127.799 °C
• PSA: 39.19000
• Density: 1.248 g/cm³
• LogP: 1.83000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Chloro-5-methylpicolinate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 4-chloro-5-methylpicolinate

There total 2 articles about Methyl 4-chloro-5-methylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.3%

methyl 5-methyl-2-pyridinecarboxylate N-oxide (401792-77-6) → methyl 4-chloro-5-methylpyridine-2-carboxylate (1104455-41-5) + methyl 6-chloro-5-methylpyridine-2-carboxylate (178421-22-2)

Guidance literature:

methyl 5-methyl-2-pyridinecarboxylate N-oxide; With trichlorophosphate; In chloroform; at 80 ℃; for 0.0833333h;

With potassium carbonate; In chloroform; water; pH=7;

Reference yield:

methanol (67-56-1) + 2-carboxy-5-methylpyridine (4434-13-3) → methyl 4-chloro-5-methylpyridine-2-carboxylate (1104455-41-5)

Guidance literature:

2-carboxy-5-methylpyridine; With thionyl chloride; N,N-dimethyl-formamide; sodium bromide; for 17h; Reflux; Inert atmosphere;

methanol; With N-ethyl-N,N-diisopropylamine; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield: 49.0%

methyl 4-chloro-5-methylpyridine-2-carboxylate (1104455-41-5) + 2-tri-n-butylstannylpyridine (17997-47-6) → C13H12N2O2

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 160 ℃; for 1h; Microwave irradiation;

upstream raw materials:

methyl 5-methyl-2-pyridinecarboxylate N-oxide

methanol

2-carboxy-5-methylpyridine