2-Piperidineacetic acid, α-phenyl-, ethyl ester, hydrochloride (1:1)

Base Information

• Chemical Name: 2-Piperidineacetic acid, α-phenyl-, ethyl ester, hydrochloride (1:1)
• CAS No.: 19716-79-1
• Molecular Formula: C15H21NO2.ClH
• Molecular Weight: 283.7937
• Hs Code.: 2933399090
• Mol file: 19716-79-1.mol

Synonyms:LogP

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Chemical Property of 2-Piperidineacetic acid, α-phenyl-, ethyl ester, hydrochloride (1:1)

Chemical Property:

• Melting Point: 197-199℃
• PSA: 38.33000
• LogP: 3.60620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethylphenidate Hydrochloride is the transesterification metabolite of Methylphenidate (M325880) and ethanol.

Technology Process of 2-Piperidineacetic acid, α-phenyl-, ethyl ester, hydrochloride (1:1)

There total 1 articles about 2-Piperidineacetic acid, α-phenyl-, ethyl ester, hydrochloride (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanol (64-17-5) + (±)-erythro/threo-2-phenyl-2-(piperidin-2-yl)acetamide (19395-39-2) → ethylphenidate hydrochloride (19716-79-1,851764-84-6,1246815-21-3,851764-85-7)

Guidance literature:

ethanol; (±)-erythro/threo-2-phenyl-2-(piperidin-2-yl)acetamide; With sulfuric acid; at 2 - 95 ℃;

With hydrogenchloride; In isopropyl alcohol; at 5 - 65 ℃;

Reference yield:

2,2,3,3,3-pentafluoropropanoic anhydride (356-42-3) + ethylphenidate hydrochloride (19716-79-1,851764-84-6,1246815-21-3,851764-85-7) → (1-pentafluoropropionyl-piperidin-2-yl)-phenyl-acetic acid ethyl ester (103298-57-3)

Guidance literature:

With pyridine; In hexane; benzene; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.34.1701

upstream raw materials:

ethanol

(±)-erythro/threo-2-phenyl-2-(piperidin-2-yl)acetamide

Downstream raw materials:

(1-pentafluoropropionyl-piperidin-2-yl)-phenyl-acetic acid ethyl ester