8-Chloro-6-nitroquinoline

Base Information

• Chemical Name: 8-Chloro-6-nitroquinoline
• CAS No.: 121465-04-1
• Molecular Formula: C9H5ClN2O2
• Molecular Weight: 208.604
• European Community (EC) Number: 634-231-9
• DSSTox Substance ID: DTXSID20403852
• Wikidata: Q82207701
• Mol file: 121465-04-1.mol

Synonyms:8-chloro-6-nitroquinoline;121465-04-1;Quinoline, 8-chloro-6-nitro-;DTXSID20403852;SMSSF-0625509;AKOS016004067;AMS_CNC_ID-390555741;SB69912;F73306;A891684

Chemical Property of 8-Chloro-6-nitroquinoline

Chemical Property:

• PSA: 58.71000
• LogP: 3.31960
• Storage Temp.: 2-8°C
• XLogP3: 2.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 208.0039551
• Heavy Atom Count: 14
• Complexity: 231

Purity/Quality:

97% ^*data from raw suppliers

8-CHLORO-6-NITROQUINOLINE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=CC(=CC(=C2N=C1)Cl)[N+](=O)[O-]

Technology Process of 8-Chloro-6-nitroquinoline

There total 1 articles about 8-Chloro-6-nitroquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) + 2-Chloro-4-nitroaniline (121-87-9) → 8-chloro-6-nitroquinoline (121465-04-1)

Guidance literature:

glycerol; 2-Chloro-4-nitroaniline; With sulfuric acid; 4-chloro-aniline; Reflux;

With ammonia; In water;

DOI:10.1016/j.cclet.2010.10.005

Reference yield: 96.0%

8-chloro-6-nitroquinoline (121465-04-1) → 6-aminoquinoline (580-15-4)

Guidance literature:

With palladium on activated charcoal; hydrazine hydrate; In water;

DOI:10.1016/j.cclet.2010.10.005

Reference yield: 90.0%

8-chloro-6-nitroquinoline (121465-04-1) → 8-chloro-[6]quinolylamine (50358-62-8)

Guidance literature:

8-chloro-6-nitroquinoline; With hydrogenchloride; tin(ll) chloride; In water; for 1h; Heating;

With ammonia; In water;

DOI:10.1016/j.cclet.2010.10.005

upstream raw materials:

glycerol

2-Chloro-4-nitroaniline

Downstream raw materials:

8-chloro-[6]quinolylamine

N-(8-chloro-[6]quinolyl)-anthranilic acid

4-chloro-2-(8-chloro-[6]quinolylamino)-benzoic acid

6-aminoquinoline