Ethyl 2,2-difluorobutanoate

Base Information

• Chemical Name: Ethyl 2,2-difluorobutanoate
• CAS No.: 2368-92-5
• Molecular Formula: C6H10F2O2
• Molecular Weight: 152.141
• Mol file: 2368-92-5.mol

Synonyms:2,2-Difluorobutyric acid;;2,2-Difluor-buttersaeure-aethylester;;2,2-difluoro-butyric acid ethyl ester;;2,2-Difluor-buttersaeure;;

Chemical Property of Ethyl 2,2-difluorobutanoate

Chemical Property:

• Refractive Index: 1.3665
• Boiling Point: 124 oC
• Flash Point: 29 oC
• PSA: 26.30000
• Density: 1.071
• LogP: 1.59480

Purity/Quality:

99% ^*data from raw suppliers

ETHYL-2,2-DIFLUOROBUTANOATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 2,2-difluorobutanoate

There total 3 articles about Ethyl 2,2-difluorobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-Ethoxy-1-trimethylsilyloxy-1-buten (65946-52-3) → 2-fluoro-butyric acid ethyl ester (327-46-8) + ethyl 2,2-difluorobutanoate (2368-92-5)

Guidance literature:

With fluorine; In trichlorofluoromethane; at -78 ℃;

DOI:10.1021/jo00297a090

Reference yield:

Ethyl bromodifluoroacetate (667-27-6) + ethyl iodide (75-03-6) → ethyl 2,2-difluorobutanoate (2368-92-5)

Guidance literature:

With copper; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere;

DOI:10.1039/d0ob02546a

Reference yield:

2,2-difluorobutanoic acid (2366-62-3) → ethyl 2,2-difluorobutanoate (2368-92-5)

Guidance literature:

With toluene-4-sulfonic acid; Verestern;

upstream raw materials:

2,2-difluorobutanoic acid

1-Ethoxy-1-trimethylsilyloxy-1-buten

Ethyl bromodifluoroacetate

ethyl iodide

Downstream raw materials:

2,2-difluorobutanoic acid

ethyl 4,4-difluoro-3-oxobutyrate