Butanoic acid, 2,4-difluoro-3-oxo-, ethyl ester

Base Information

• Chemical Name: Butanoic acid, 2,4-difluoro-3-oxo-, ethyl ester
• CAS No.: 363-77-9
• Molecular Formula: C6H8F2O3
• Molecular Weight: 166.125
• Mol file: 363-77-9.mol

Synonyms:DYSPROSIUM(II) IODIDE ANHYDROUS POWDE&;Dysprosium(II) iodid;Dysprosium(II) iodide

Chemical Property of Butanoic acid, 2,4-difluoro-3-oxo-, ethyl ester

Chemical Property:

• Boiling Point: 97 °C(Press: 14 Torr)
• PKA: 8.08±0.46(Predicted)
• PSA: 43.37000
• Density: 1.191±0.06 g/cm3(Predicted)
• LogP: 0.42620

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanoic acid, 2,4-difluoro-3-oxo-, ethyl ester

There total 4 articles about Butanoic acid, 2,4-difluoro-3-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

ethyl 2-fluoroacetate (459-72-3) → ethyl 2,4-difluoro-3-oxobutanoate (363-77-9)

Guidance literature:

With sodium hydride; In diethyl ether; mineral oil; for 4h; Reflux;

DOI:10.1016/j.bioorg.2020.103824

Reference yield: 10.0%

ethyl acetoacetate (141-97-9) → ethyl-2-fluoroacetoacetate (1522-41-4) + 2,2-difluoro-3-oxobutyric acid ethyl ester (2266-48-0) + ethyl 2,4-difluoro-3-oxobutanoate (363-77-9)

Guidance literature:

With fluorine; In formic acid; at 10 - 15 ℃;

DOI:10.1016/0040-4020(95)00883-A

Reference yield:

ethyl 2-fluoroacetate (459-72-3) + methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate (108865-84-5) → ethyl 2,4-difluoro-3-oxobutanoate (363-77-9)

Guidance literature:

With sodium; In diethyl ether; ethanol;

DOI:10.1039/jr9640002497

upstream raw materials:

ethyl 2-fluoroacetate

methyl 2,2-dimethyl-1,3-dioxolane-4-carboxylate

ethyl acetoacetate

Downstream raw materials:

1,3-difluoro-propan-2-one

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