108865-84-5

Basic information

• Product Name: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,methylester(9CI)
• Synonyms: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,methylester(9CI);1,3-Dioxolane-4-carboxylicacid,2,2-diMethyl-Methylester;Methyl (^+)-2,2-diMethyl-1,3-dioxolane-4-carboxylate, 97+%;2,2-DiMethyl-[1,3]dioxolane-4-carboxylic acid Methyl ester;Methyl (+/-)-2,2-diMethyl-1,3-dioxygenolane-4-carboxylate;)-2,2-dimethyl-1,3-dioxolane-4-carboxylate;Methyl (±
• CAS NO: 108865-84-5
• Molecular Formula: C₇H₁₂O₄
• Molecular Weight: 160.17
• Product Categories: CARBOXYLICESTER
• Mol File: 108865-84-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 70-75℃/10mm
• Flash Point: 173°(343°F)
• Appearance: /
• Density: 1.106
• CAS DataBase Reference: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,methylester(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,methylester(9CI)(108865-84-5)
• EPA Substance Registry System: 1,3-Dioxolane-4-carboxylicacid,2,2-dimethyl-,methylester(9CI)(108865-84-5)

Safety Data

• Hazardous Substances Data: 108865-84-5(Hazardous Substances Data)

Usage

Uses

Methyl (+/-)-2,2-dimethyl-1,3-dioxolane-4-carboxylate is used as pharmaceutical intermediate.

Upstream product

• 615-34-9 methyl glycerate 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 74-88-4 methyl iodide 
• 77-78-1 dimethyl sulfate 
• 5736-06-1 2,3-dihydroxypropionic acid isopropylidene ketal 
• 77-76-9 2,2-dimethoxy-propane 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 83400-91-3 2,2-dimethyl-1,3-dioxolane-4-carboxylic acid potassium salt 
• 186581-53-3 diazomethane 
• 104753-58-4 2,2-dimethyl-1,3-dioxolane-4-carboxylic acid,sodium salt 
• 67-64-1 acetone 

Downstream Products

• 915193-74-7 (+/-)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid hydrazide 
• 148065-34-3 (+/-)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid amide 
• 5736-06-1 2,3-dihydroxypropionic acid isopropylidene ketal 
• 477842-53-8 4-(1-Hydroxy-3-phenylsulfanyl-propyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 1026631-82-2 4-(1-Hydroxy-2-phenylselanyl-ethyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid methyl ester 
• 60456-21-5 methyl (4S)-2,2-dimethyl-1,3-dioxolane-4-carboxylate 
• 1344072-77-0 C₂₇H₄₆O₇Si 
• 1344072-80-5 C₂₀H₂₈O₆ 
• 1344072-92-9 C₂₀H₃₀O₆ 
• 1344072-82-7 C₂₃H₃₄O₆ 
• 1344073-08-0 C₃₀H₄₁F₃O₇Si 
• 1344073-09-1 C₂₃H₂₃F₃O₆ 
• 1344073-11-5 C₂₈H₄₅F₃O₇Si 
• 1344073-16-0 C₂₁H₂₇F₃O₆ 

Relevant articles and documents

Concise Asymmetric Synthesis of Kweichowenol A

An asymmetric 11-step synthesis of the polyoxygenated cyclohexene natural product kweichowenol A from the traditional Chinese medicinal herb Uvaria kweichowesis is reported. The oxygenation pattern was installed on a linear precursor by exploiting the acyclic stereocontrol of the Kiyooka aldol reaction, as well as Cram chelate-controlled Grignard reactions. Ring-closing metathesis and a selective benzoylation then gave the natural product.

SUBSTITUTED OXAZOLIDINONES

The present invention relates to new oxazolidinone modulators of skeletal muscle function and tone, pharmaceutical compositions thereof, and methods of use thereof.

A practical RuCl3-catalyzed oxidation using trichlproisocyanuric acid as a stoichiometric oxidant under mild nonacidic conditions

The combined use of catalytic RuCl3 (1.0 mol %) and stoichiometric trichloroisocyanuric acid (TCCA; 1.0 equiv) in the presence of n-Bu4NBr (2.0 mol %) and K2CO3 (3.0 equiv) in 1:1 MeCN/H2O at 25-45°C allows smooth oxidation of primary alcohols to carboxylic acids. Secondary alcohols can be oxidized to ketones when using the same set of the reagents in 1:1 MeCN/ H2O or 1:1 AcOEt/H2O. By proceeding under the nonacidic biphasic conditions dispensing with hazardous reagents, the oxidation reactions are applicable to structurally diverse alcohols, easy to work up, environmentally benign, and basically high-yielding.