2,6-dichloro-3-fluorobenzonitrile

Base Information

• Chemical Name: 2,6-dichloro-3-fluorobenzonitrile
• CAS No.: 136514-16-4
• Molecular Formula: C7H2Cl2FN
• Molecular Weight: 190
• Mol file: 136514-16-4.mol

Synonyms:Benzonitrile, 2,6-dichloro-3-fluoro-;

Chemical Property of 2,6-dichloro-3-fluorobenzonitrile

Chemical Property:

• Melting Point: 69-71 °C
• Boiling Point: 277.5±35.0 °C(Predicted)
• PSA: 23.79000
• Density: 1.49±0.1 g/cm3(Predicted)
• LogP: 3.00418

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-dichloro-3-fluorobenzonitrile

There total 4 articles about 2,6-dichloro-3-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.1%

2,6?dichloro?3?fluorobenzamide → 2,6-dichloro-3-fluoro-benzonitrile (136514-16-4)

Guidance literature:

With pyridine; thionyl chloride; for 4h; Reagent/catalyst; Reflux;

Reference yield:

2',6'-dichloro-3'-fluoroacetophenone (290835-85-7) → 2,6-dichloro-3-fluoro-benzonitrile (136514-16-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: chlorine / acetic acid / 5 h / 60 °C

1.2: 60 - 100 °C

2.1: ammonia / ethanol / 20 °C

3.1: bis(trichloromethyl) carbonate; N,N-dimethyl-formamide / ethyl acetate / 60 °C

With bis(trichloromethyl) carbonate; ammonia; chlorine; N,N-dimethyl-formamide; In ethanol; acetic acid; ethyl acetate;

DOI:10.3184/174751911X13129873455321

Reference yield:

2,6-dichloro-3-fluoro-benzaldoxime + sodium sulfate (7757-82-6) → 2,6-dichloro-3-fluoro-benzonitrile (136514-16-4)

Guidance literature:

With acetic anhydride; In dichloromethane;

upstream raw materials:

sodium sulfate

2',6'-dichloro-3'-fluoroacetophenone

Refernces

• 1、 -. "Preparation method of pentafluorobenzonitrile". Paragraph 0026; 0027; 0028; 0029; 0030; 0031; 0032; 0033. . Retrieved 2017/07/19.
• 2、 -. "Herbicidal compositions based on 2,6-dichloro-3-fluoro-benzonitrile, and new intermediates". . . Retrieved 2008/06/13.