2-CHLORO-6-(4-METHANESULFONYL-PIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE

Base Information

Chemical Name:2-CHLORO-6-(4-METHANESULFONYL-PIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE
CAS No.:885675-66-1
Molecular Formula:C16H22ClN5O3S2
Molecular Weight:431.967
Hs Code.:2934999090
Mol file:885675-66-1.mol

Synonyms:2-chloro-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine;2-chloro-6-((4-methanesulfonylpiperazin-1-yl)methyl)-4-morpholinothieno[3,2-d]pyrimidine;2-chloro-6-(4-methylsulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine;4-(2-chloro-6-((4-N-(methanesulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine;4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine;2-chloro-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-Thieno[3,2-d]pyrimidine;

Suppliers and Price of 2-CHLORO-6-(4-METHANESULFONYL-PIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)-methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 95+%
1g
$ 1647.00

Matrix Scientific
4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)-methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 95+%
250mg
$ 742.00

Crysdot
4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 95+%
1g
$ 772.00

Chemenu
4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)-methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 95%
1g
$ 729.00

American Custom Chemicals Corporation
4-(2-CHLORO-6-((4-(METHYLSULFONYL)PIPERAZIN-1-YL)METHYL)THIENO[3,2-D]PYRIMIDIN-4-YL)MORPHOLINE 95.00%
5MG
$ 500.01

AK Scientific
4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
1g
$ 2273.00

AK Scientific
4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine
250mg
$ 1051.00

Total 16 raw suppliers

Chemical Property of 2-CHLORO-6-(4-METHANESULFONYL-PIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE

Chemical Property:

PSA：115.49000
LogP:2.28010
Storage Temp.:2-8°C

Purity/Quality:

NLT 98% ^*data from raw suppliers

4-(2-Chloro-6-((4-(methylsulfonyl)piperazin-1-yl)-methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-CHLORO-6-(4-METHANESULFONYL-PIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE

There total 14 articles about 2-CHLORO-6-(4-METHANESULFONYL-PIPERAZIN-1-YLMETHYL)-4-MORPHOLIN-4-YL-THIENO[3,2-D]PYRIMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

: 55276-43-2
4-methanesulfonylpiperazine

: 1381841-06-0
4-(2-chloro-6-(chloromethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine

: 885675-66-1
4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In i-Amyl alcohol; for 11h; Reflux;
DOI:10.1248/cpb.c12-00342

Reference yield: 93.0%

: 1416327-30-4
1-((4-(methylsulfonyl)piperazin-1-yl)methyl)-1H-benzotriazole

: 16234-15-4
2-chloro-4-morpholinothieno[3,2-d]pyrimidine

: 885675-66-1
4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine

Guidance literature:: 2-chloro-4-morpholinothieno[3,2-d]pyrimidine; With isopropylmagnesium chloride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; hexane; at -10 ℃; Inert atmosphere;

1-((4-(methylsulfonyl)piperazin-1-yl)methyl)-1H-benzotriazole; With zinc(II) chloride; In tetrahydrofuran; hexane; at -20 - 10 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/op3002992

Reference yield: 85.0%

: 885618-31-5
2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde

: 161357-89-7
1-(methylsulfonyl)piperazine hydrochloride

: 885675-66-1
4-(2-chloro-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]-pyrimidin-4-yl)morpholine

Guidance literature:: 2-chloro-4-morpholinothieno[3,2-d]pyrimidine-6-carbaldehyde; 1-(methylsulfonyl)piperazine hydrochloride; With sodium acetate; trimethyl orthoformate; In acetonitrile; at 45 ℃; for 5h; Inert atmosphere; Large scale;

With sodium tris(acetoxy)borohydride; In acetonitrile; for 7h; Solvent; Inert atmosphere; Large scale;
DOI:10.1021/op3002992