2-(2,3-dihydrobenzofuran-5-yl)-1-Morpholinoethanethione

Base Information

• Chemical Name: 2-(2,3-dihydrobenzofuran-5-yl)-1-Morpholinoethanethione
• CAS No.: 97483-11-9
• Molecular Formula: C14H17NO2S
• Molecular Weight: 263.36
• Hs Code.: 2932990090
• Mol file: 97483-11-9.mol

Synonyms:<2.3-Dihydro-benzofuryl-(2)>-essigsaeure;2-(2,3-dihydrobenzofuran-5-yl)-1-morpholin-4-yl-ethanethione;2-Benzofuranacetic acid,2,3-dihydro;(2,3-dihydro-benzofuran-2-yl)-acetic acid;2-(2,3-dihydrobenzofuran-2-yl)-acetic acid;2-(2,3-dihydrobenzofuran-5-yl)acetothiomorpholide;

Chemical Property of 2-(2,3-dihydrobenzofuran-5-yl)-1-Morpholinoethanethione

Chemical Property:

• PSA: 53.79000
• LogP: 1.76150

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,3-dihydrobenzofuran-5-yl)-1-Morpholinoethanethione

There total 2 articles about 2-(2,3-dihydrobenzofuran-5-yl)-1-Morpholinoethanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

morpholine (110-91-8,99108-56-2) + 1-(2,3-dihydrobenzofuran-5-yl)ethanone (90843-31-5) → 2-(2,3-dihydrobenzofuran-5-yl)acetothiomorpholide (97483-11-9)

Guidance literature:

With toluene-4-sulfonic acid; sulfur; at 130 ℃; for 10h;

Reference yield:

2.3-dihydrobenzofuran (496-16-2) → 2-(2,3-dihydrobenzofuran-5-yl)acetothiomorpholide (97483-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / AlCl₃ / CH₂Cl₂ / 0.5 h / -6 °C

2: 50.3 percent / sulfur, p-toluenesulfonic acid / 5 h / Heating

With aluminium trichloride; toluene-4-sulfonic acid; sulfur; In dichloromethane;

DOI:10.1021/jm00161a030

Reference yield: 70.0%

2-(2,3-dihydrobenzofuran-5-yl)acetothiomorpholide (97483-11-9) → 2,3-dihydrobenzofuran-5-acetic acid (69999-16-2)

Guidance literature:

With sulfuric acid; water; acetic acid; for 4h; Heating;

DOI:10.1021/jm00161a030

upstream raw materials:

morpholine

1-(2,3-dihydrobenzofuran-5-yl)ethanone

2.3-dihydrobenzofuran

Downstream raw materials:

2,3-dihydrobenzofuran-5-acetic acid

ethyl 2,3-dihydrobenzofuran-5-ylacetate

7-benzoylbenzofuran-5-ylacetic acid

(7-Benzoyl-2,3-dihydro-benzofuran-5-yl)-acetic acid

Refernces

• 1、 Dunn,Ackerman,Tomolonis. "Analgetic and antiinflammatory 7-aroylbenzofuran-5-ylacetic acids and 7-aroylbenzothiophene-5-ylacetic acids". . p. 2326 - 2329. Retrieved 2007/10/02.