4-BroMo-1-Methanesulfonyl-2-Methylbenzene

Base Information

• Chemical Name: 4-BroMo-1-Methanesulfonyl-2-Methylbenzene
• CAS No.: 99768-21-5
• Molecular Formula: C8H9BrO2S
• Molecular Weight: 249.128
• Hs Code.: 2904909090
• Mol file: 99768-21-5.mol

Synonyms:4-BroMo-1-Methanesulfonyl-2-Methylbenzene;4-bromo-2-methyl-1-(methylsulfonyl)benzene

Chemical Property of 4-BroMo-1-Methanesulfonyl-2-Methylbenzene

Chemical Property:

• PSA: 42.52000
• LogP: 3.24180
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform, DMSO (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

4-Bromo-1-methanesulfonyl-2-methylbenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-1-Methanesulfonyl-2-Methylbenzene

There total 4 articles about 4-BroMo-1-Methanesulfonyl-2-Methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-bromo-2-toluenesulfonyl chloride (139937-37-4) + bromoacetic acid (79-08-3) → 4-bromo-2-methyl-1-(methylsulfonyl)benzene (99768-21-5)

Guidance literature:

5-bromo-2-toluenesulfonyl chloride; With sodium hydrogencarbonate; sodium sulfite; In water; at 75 ℃; for 1.16667h;

bromoacetic acid; In water; at 105 ℃;

Reference yield:

2-methyl-4-bromoiodobenzene (116632-39-4) + sodium methansulfinate (20277-69-4) → 4-bromo-2-methyl-1-(methylsulfonyl)benzene (99768-21-5)

Guidance literature:

With copper(l) iodide; In dimethyl sulfoxide; at 100 - 125 ℃; for 3.33333h; Microwave irradiation;

Reference yield:

methyl o-tolyl sulfide (14092-00-3) → 4-bromo-2-methyl-1-(methylsulfonyl)benzene (99768-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrachloromethane; N-bromo-succinimide

2: aqueous H₂O₂; acetic acid

With tetrachloromethane; N-Bromosuccinimide; dihydrogen peroxide; acetic acid;

upstream raw materials:

methyl 4-bromo-2-methylphenyl sulphide

methyl o-tolyl sulfide

2-methyl-4-bromoiodobenzene

sodium methansulfinate

Downstream raw materials:

1-(3-methyl-4-(methylsulfonyl)phenyl)-4-(1-(5-propylpyrimidin-2-yl)piperidin-4-yloxy)pyridin-2(1H)-one