4-Cyano-3,5-difluorobenzeneboronic acid pinacol ester, 96%

Base Information

• Chemical Name: 4-Cyano-3,5-difluorobenzeneboronic acid pinacol ester, 96%
• CAS No.: 1003298-73-4
• Molecular Formula: C13H14BF2NO2
• Molecular Weight: 265.067
• Hs Code.: 2931900090
• Mol file: 1003298-73-4.mol

Synonyms:4-Cyano-3,5-difluorobenzeneboronic acid pinacol ester, 96%;2,6-Difluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Chemical Property of 4-Cyano-3,5-difluorobenzeneboronic acid pinacol ester, 96%

Chemical Property:

• Boiling Point: 342.2±42.0 °C(Predicted)
• PSA: 42.25000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 2.13568
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2,6-difluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Cyano-3,5-difluorobenzeneboronic acid pinacol ester, 96%

There total 2 articles about 4-Cyano-3,5-difluorobenzeneboronic acid pinacol ester, 96% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-2,6-difluorobenzonitrile (123843-67-4) + bis(pinacol)diborane (73183-34-3) → 2,6-difluoro-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1003298-73-4)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; In 1,4-dioxane; at 110 ℃; for 2h; Inert atmosphere;

Reference yield:

→ 2,6-difluoro-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1003298-73-4)

Guidance literature:

With [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); potassium acetate; In 1,4-dioxane; at 100 ℃; for 18h;

Reference yield: 68.0%

2,6-difluoro-4-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile (1003298-73-4) → C15H5F8N

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In water; toluene; at 110 ℃; for 16h; Inert atmosphere;

upstream raw materials:

4-bromo-2,6-difluorobenzonitrile

bis(pinacol)diborane

Downstream raw materials:

3,5-difluoro-4-cyanophenylboronic acid