3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine

Base Information

• Chemical Name: 3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine
• CAS No.: 924869-13-6
• Molecular Formula: C₇H₄BrN₃O
• Molecular Weight: 226.032
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID00594752
• Wikidata: Q82489657
• Mol file: 924869-13-6.mol

Synonyms:924869-13-6;3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine;2-(5-Bromopyridin-3-yl)-1,3,4-oxadiazole;SCHEMBL4171974;DTXSID00594752;ZLB86913;MFCD08444031;AKOS005072320;EA-0805;DA-24003;CS-0199491;E78685;A925926

Chemical Property of 3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine

Chemical Property:

• Melting Point: 182～183℃
• PSA: 51.81000
• LogP: 1.89410
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 224.95377
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC=C1Br)C2=NN=CO2

Technology Process of 3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine

There total 1 articles about 3-Bromo-5-(1,3,4-oxadiazol-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

5-bromo-3-pyridinecarboxylic acid (20826-04-4) + formic acid hydrazide (624-84-0) → 3-bromo-5-(1,3,4-oxadiazol-2-yl)pyridine (924869-13-6)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; at 80 ℃; Inert atmosphere;

DOI:10.1016/j.tet.2009.09.114

Reference yield:

3-bromo-5-(1,3,4-oxadiazol-2-yl)pyridine (924869-13-6) → (4S,6S)-4-(5-(5-(1,3,4-oxadiazol-2-yl)pyridin-3-yl)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine (1624604-19-8)

Guidance literature:

upstream raw materials:

5-bromo-3-pyridinecarboxylic acid

formic acid hydrazide

Downstream raw materials:

(4S,6S)-4-(5-(5-(1,3,4-oxadiazol-2-yl)pyridin-3-yl)-2-fluorophenyl)-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-2-amine