Technology Process of 4,7-DiMethoxy-6-azaindole Hydrochloride
There total 2 articles about 4,7-DiMethoxy-6-azaindole Hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale
2.1: tert.-butylnitrite; sulfuric acid / 9.5 h / 20 - 43 °C / Large scale
3.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale
4.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale
5.1: 5%-palladium/activated carbon; hydrogen / ethyl acetate / 24 h / 25 - 35 °C / 1275.13 - 1500.15 Torr / Autoclave; Large scale
5.2: 10 - 30 °C / Large scale
With
methanol; copper(l) iodide; tert.-butylnitrite; propanoic acid methyl ester; sulfuric acid; 5%-palladium/activated carbon; hydrogen; nitric acid;
In
tetrahydrofuran; water; ethyl acetate; N,N-dimethyl-formamide;
2.1: |Sandmeyer Reaction / 3.1: |Leimgruber-Batcho Indole Synthesis / 5.1: |Leimgruber-Batcho Indole Synthesis;
DOI:10.1021/acs.oprd.7b00134
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sulfuric acid; nitric acid / water / 7 h / 25 - 33 °C / Large scale
2.1: tert.-butylnitrite; sulfuric acid / 9.5 h / 20 - 43 °C / Large scale
3.1: N,N-dimethyl-formamide / 80 - 100 °C / Large scale
4.1: methanol; propanoic acid methyl ester; copper(l) iodide / tetrahydrofuran / 21 h / 30 - 72 °C / Large scale
5.1: formic acid; triethylamine; palladium 10% on activated carbon / tetrahydrofuran; ethanol / 7 h / 50 - 55 °C / Large scale
5.2: Large scale
With
methanol; copper(l) iodide; formic acid; tert.-butylnitrite; propanoic acid methyl ester; sulfuric acid; palladium 10% on activated carbon; nitric acid; triethylamine;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
2.1: |Sandmeyer Reaction / 3.1: |Leimgruber-Batcho Indole Synthesis;
DOI:10.1021/acs.oprd.7b00134
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: trichlorophosphate / neat (no solvent) / 15 h / 40 - 102 °C / Large scale
2.1: methanol / toluene / 8 h / 45 - 55 °C / Large scale
3.1: Methyl isobutyl carbinol / 76 h / 130 - 145 °C / Large scale
4.1: isopropylmagnesium chloride; pyridine / 2-methyltetrahydrofuran / -25 - -10 °C / Large scale
4.2: 3 h / -25 - -10 °C / Large scale
5.1: tetra-(n-butyl)ammonium iodide; potassium carbonate / acetonitrile / 16 h / 20 °C / Large scale
6.1: potassium carbonate / acetonitrile / 4 h / 20 - 25 °C / Large scale
6.2: 12 h / 85 °C / Large scale
7.1: chlorine; water / dichloromethane / 0 °C
With
pyridine; methanol; Methyl isobutyl carbinol; water; isopropylmagnesium chloride; chlorine; tetra-(n-butyl)ammonium iodide; potassium carbonate; trichlorophosphate;
In
2-methyltetrahydrofuran; dichloromethane; toluene; acetonitrile;
DOI:10.1021/acs.oprd.7b00134
