(S)-2-AMINO-2-CYCLOHEXYL-ETHANOL

Base Information

• Chemical Name: (S)-2-AMINO-2-CYCLOHEXYL-ETHANOL
• CAS No.: 845714-30-9
• Molecular Formula: C8H17NO
• Molecular Weight: 143.229
• Mol file: 845714-30-9.mol

Synonyms:(S)-2-Amino-2-cyclohexylethanol;

Chemical Property of (S)-2-AMINO-2-CYCLOHEXYL-ETHANOL

Chemical Property:

• Boiling Point: 274 ºC
• PKA: 12.85±0.10(Predicted)
• Flash Point: 119 ºC
• PSA: 46.25000
• Density: 0.999
• LogP: 1.58660
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%, ^*data from raw suppliers

(S)-2-Amino-2-cyclohexylethanol 98% ^*data from reagent suppliers

Safty Information:

• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-AMINO-2-CYCLOHEXYL-ETHANOL

There total 5 articles about (S)-2-AMINO-2-CYCLOHEXYL-ETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

(2S)-amino(cyclohexyl)ethanoic acid (14328-51-9) → (S)-2-amino-2-cyclohexylethan -1-ol (845714-30-9)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 6h; Cooling with ice; Reflux;

Reference yield:

(S)-2-benzylamino-2-cyclohexyl-ethanol (101355-73-1) → (S)-2-amino-2-cyclohexylethan -1-ol (845714-30-9)

Guidance literature:

With palladium on activated charcoal; oxalic acid;

DOI:10.1039/jr9570002073

Reference yield:

2-cyclohexylglycine (5664-29-9) → (S)-2-amino-2-cyclohexylethan -1-ol (845714-30-9)

Guidance literature:

Multi-step reaction with 4 steps

2: quinine

3: LiAlH₄; diethyl ether

4: palladium/charcoal; aq.-ethanolic oxalic acid

With palladium on activated charcoal; lithium aluminium tetrahydride; diethyl ether; oxalic acid; Quinine;

DOI:10.1039/jr9570002073

upstream raw materials:

(S)-2-benzylamino-2-cyclohexyl-ethanol

2-cyclohexylglycine

N-benzoyl-α-cyclohexylglycine

(S)-benzoylamino-cyclohexyl-acetic acid

Downstream raw materials:

(S)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid ((S)-1-cyclohexyl-2-hydroxy-ethyl)-amide

(R)-2,3-dihydro-furo[2,3-b]pyridine-3-carboxylic acid ((S)-1-cyclohexyl-2-hydroxy-ethyl)-amide

3,4-dihydro-2H-pyrano[2,3-b]pyridine-4-carboxylic acid ((S)-1-cyclohexyl-2-hydroxy-ethyl)-amide

Refernces

• 1、 -. "HETEROCYCLIC COMPOUNDS AND USE THEREOF AS MODULATORS OF TYPE III RECEPTOR TYROSINE KINASES". Paragraph 0533. . Retrieved 2016/08/03.
• 2、 Cole, Derek C.,Stock, Joseph R.,Kreft, Anthony F.,Antane, Madelene,Aschmies, Suzan H.,Atchison, Kevin P.,Casebier, David S.,Comery, Thomas A.,Diamantidis, George,Ellingboe, John W.,Harrison, Boyd L.,Hu, Yun,Jin, Mei,Kubrak, Dennis M.,Lu, Peimin,Mann, Charles W.,Martone, Robert L.,Moore, William J.,Oganesian, Aram,Riddell, David R.,Sonnenberg-Reines, June,Sun, Shaiu-Ching,Wagner, Erik,Wang, Zheng,Woller, Kevin R.,Xu, Zheng,Zhou, Hua,Jacobsen, J. Steven. "(S)-N-(5-Chlorothiophene-2-sulfonyl)-β,β-diethylalaninol a Notch-1-sparing γ-secretase inhibitor". scheme or table. p. 926 - 929. Retrieved 2009/09/06.