Cyclohexaneacetic acid, a-(benzoylamino)-

Base Information

• Chemical Name: Cyclohexaneacetic acid, a-(benzoylamino)-
• CAS No.: 59759-91-0
• Molecular Formula: C15H19NO3
• Molecular Weight: 261.321
• Mol file: 59759-91-0.mol

Synonyms:

Chemical Property of Cyclohexaneacetic acid, a-(benzoylamino)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclohexaneacetic acid, a-(benzoylamino)-

There total 10 articles about Cyclohexaneacetic acid, a-(benzoylamino)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C18H19F6NO3 → (S)-benzoylamino-cyclohexyl-acetic acid (145416-94-0) + (R)-benzoylamino-cyclohexyl-acetic acid (5963-46-2,59759-91-0,145416-94-0)

Guidance literature:

With C₂₈H₃₀N₃O₂⁽¹⁺⁾*Br^(1-); sodium hydroxide; In chloroform; at 0 ℃; for 24h;

DOI:10.1021/acscatal.8b00693

Reference yield: 82.0%

carbon monoxide (201230-82-2) + benzamide (55-21-0,27208-38-4) + cyclohexanecarbaldehyde (2043-61-0) → N-benzoyl-α-cyclohexylglycine (59759-91-0)

Guidance literature:

With 3-ethyl-1-methyl-1H-imidazol-3-ium bromide; triphenylphosphine; palladium(II) bromide; at 100 ℃; for 15h; under 45004.5 Torr;

DOI:10.1055/s-2006-950270

Reference yield: 70.0%

carbon monoxide (201230-82-2) + benzonitrile (100-47-0) + cyclohexanecarbaldehyde (2043-61-0) → N-benzoyl-α-cyclohexylglycine (59759-91-0)

Guidance literature:

With 1-methyl-pyrrolidin-2-one; sulfuric acid; lithium bromide; palladium on activated charcoal; at 120 ℃; for 12h; under 45003.6 Torr;

DOI:10.1016/S0040-4039(99)00801-1

upstream raw materials:

2-cyclohexylglycine

benzoyl chloride

N-Benzoyl-α-cyclohexylglycine amide

carbon monoxide

Downstream raw materials:

(S)-benzoylamino-cyclohexyl-acetic acid

(R)-benzoylamino-cyclohexyl-acetic acid

(R)-2-amino-2-cyclohexyl acetic acid

(S)-2-amino-2-cyclohexylethan -1-ol