1-(Ethoxycarbonyl)piperidine-4-carboxylic acid

Base Information

Chemical Name:1-(Ethoxycarbonyl)piperidine-4-carboxylic acid
CAS No.:118133-15-6
Molecular Formula:C9H15NO4
Molecular Weight:201.222
Hs Code.:2933399090
European Community (EC) Number:834-910-1
DSSTox Substance ID:DTXSID00425072
Wikidata:Q72471436
Mol file:118133-15-6.mol

Synonyms:1-(ethoxycarbonyl)piperidine-4-carboxylic acid;118133-15-6;1-(Ethoxycarbonyl)-4-piperidinecarboxylic acid;1-ethoxycarbonylpiperidine-4-carboxylic acid;MFCD07339354;1,4-PIPERIDINEDICARBOXYLIC ACID 1-ETHYL ESTER;ChemDiv2_002955;Ethyl 4-carboxypiperidine-1-carboxylate;1-(Ethoxycarbonyl)piperidine-4-carboxylicacid;SCHEMBL4210140;AMY6030;DTXSID00425072;BVEBMPFJSMEGJX-UHFFFAOYSA-N;HMS1377G07;1-(Ethoxycarbonyl)isonipecotic Acid;BCP08598;4-carboxy-1-ethoxycarbonylpiperidine;AKOS001105637;FA-0712;MB04303;SY034748;CS-0042603;E1208;FT-0680792;EN300-14235;1-(Ethoxycarbonyl)piperidine-4-carboxylic'acid;A893210;J-003709;F2158-1179;1-(ETHOXYCARBONYL)-4-PIPERIDINECARBOXYLIC ACID;4-Carboxy-1-(ethoxycarbonyl)piperidine, Ethyl 4-carboxypiperidine-1-carboxylate;N-(Ethoxycarbonyl)isonipecoticacid;N-(Ethoxycarbonyl)piperidine-4-carboxylicacid

Suppliers and Price of 1-(Ethoxycarbonyl)piperidine-4-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1,4-PiperidinedicarboxylicAcid1-EthylEster
10g
$ 1100.00

TCI Chemical
1-(Ethoxycarbonyl)-4-piperidinecarboxylic Acid >98.0%(GC)(T)
1g
$ 40.00

TCI Chemical
1-(Ethoxycarbonyl)-4-piperidinecarboxylic Acid >98.0%(GC)(T)
5g
$ 120.00

SynQuest Laboratories
1-(Ethoxycarbonyl)piperidine-4-carboxylic acid
5 g
$ 72.00

SynQuest Laboratories
1-(Ethoxycarbonyl)piperidine-4-carboxylic acid
1 g
$ 24.00

Medical Isotopes, Inc.
1,4-PiperidinedicarboxylicAcid1-EthylEster
1 g
$ 625.00

Matrix Scientific
1-(Ethoxycarbonyl)-4-piperidinecarboxylic acid >95%
500mg
$ 14.00

Labseeker
1-(ethoxycarbonyl)piperidine-4-carboxylicacid 95
1kg
$ 3392.00

Crysdot
1-(Ethoxycarbonyl)piperidine-4-carboxylicacid 95+%
25g
$ 211.00

Chemenu
1-(Ethoxycarbonyl)-4-piperidinecarboxylic Acid 95%
25g
$ 195.00

Total 48 raw suppliers

Chemical Property of 1-(Ethoxycarbonyl)piperidine-4-carboxylic acid

Chemical Property:

Melting Point:68-70
Boiling Point:343.0±35.0 °C(Predicted)
PKA:4.56±0.20(Predicted)
PSA：66.84000
Density:1.227
LogP:0.87740
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:201.10010796
Heavy Atom Count:14
Complexity:221

Purity/Quality:

97% ^*data from raw suppliers

1,4-PiperidinedicarboxylicAcid1-EthylEster ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xi
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)N1CCC(CC1)C(=O)O
Uses 1,4-Piperidinedicarboxylic Acid 1-Ethyl Ester, is an starting material in the synthesis of Risperidone (R525000), which is a combined serotonin (5-HT2) and dopamine (D2) receptor antagonist.

Technology Process of 1-(Ethoxycarbonyl)piperidine-4-carboxylic acid

There total 1 articles about 1-(Ethoxycarbonyl)piperidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 498-94-2
isonipecotic acid

: 541-41-3
chloroformic acid ethyl ester

: 118133-15-6
1-ethoxycarbonylpiperidine-4-carboxylic acid

Guidance literature:: With sodium hydroxide; In water; at 0 - 30 ℃; for 3h;

Reference yield: 90.0%

: 118133-15-6
1-ethoxycarbonylpiperidine-4-carboxylic acid

: 49823-14-5
1-(2-phenylethyl)-1H-imidazole

: [1-(2-phenylethyl)-1H-imidazole-2-yl](piperidin-4-yl)methanone dihydrobromide

Guidance literature:: 1-ethoxycarbonylpiperidine-4-carboxylic acid; With thionyl chloride; In N,N-dimethyl-formamide; toluene; at 50 - 55 ℃; for 2h;

1-(2-phenylethyl)-1H-imidazole; With triethylamine; In acetonitrile; at 0 - 20 ℃; for 5h; Inert atmosphere;

With hydrogen bromide; In water; at 25 - 90 ℃; for 12.16h;

Reference yield: 41.0%

: 118133-15-6
1-ethoxycarbonylpiperidine-4-carboxylic acid

: 3182-95-4
L-Phenylalaninol

: 541-41-3
chloroformic acid ethyl ester

: 147323-79-3
1-ethoxycarbonylpiperidine-4-carboxylic acid-(1S)-(1-formyl-2-phenyl)ethylamide

Guidance literature:: With sodium hydrogencarbonate; triethylamine; In sodium chloride; chloroform; water; sulfur trioxide pyridine complex; dimethyl sulfoxide;