11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine

Base Information

• Chemical Name: 11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine
• CAS No.: 142654-73-7
• Molecular Formula: C₁₇H₁₉N₃
• Molecular Weight: 265.358
• Mol file: 142654-73-7.mol

Synonyms:11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine

Chemical Property of 11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine

Chemical Property:

• Vapor Pressure: 4.43E-10mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine

There total 8 articles about 11-(piperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[1-(2-phenylethyl)-1H-imidazole-2-yl](4-piperidinyl)methanone → 11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (142654-73-7)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 25 - 140 ℃;

Reference yield:

[1-(2-phenylethyl)-1H-imidazole-2-yl](piperidin-4-yl)methanone dihydrobromide → 11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (142654-73-7)

Guidance literature:

[1-(2-phenylethyl)-1H-imidazole-2-yl](piperidin-4-yl)methanone dihydrobromide; With sodium hydroxide; In dichloromethane; water; for 0.5h;

With trifluorormethanesulfonic acid; at 25 - 145 ℃; for 10h;

Reference yield:

1-(2-phenylethyl)-1H-imidazole (49823-14-5) → 11-piperidin-4-ylidene-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine (142654-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: thionyl chloride / toluene; N,N-dimethyl-formamide / 2 h / 50 - 55 °C

1.2: 5 h / 0 - 20 °C / Inert atmosphere

1.3: 12.16 h / 25 - 90 °C

2.1: sodium hydroxide / water; dichloromethane / 0.5 h

2.2: 10 h / 25 - 145 °C

With thionyl chloride; sodium hydroxide; In dichloromethane; water; N,N-dimethyl-formamide; toluene;

upstream raw materials:

1-(2-phenylethyl)-1H-imidazole

isonipecotic acid

1-ethoxycarbonylpiperidine-4-carboxylic acid

2-phenylethanol

Downstream raw materials:

11-(1-methylpiperidin-4-ylidene)-6,11-dihydro-5H-imidazo[2,1-b][3]benzazepine