1-(5-Nitropyridin-2-yl)-piperazine hydrochloride

Base Information

Chemical Name:1-(5-Nitropyridin-2-yl)-piperazine hydrochloride
CAS No.:1185319-62-3
Molecular Formula:C₉H₁₂N₄O₂*ClH
Molecular Weight:244.681
Hs Code.:
Mol file:1185319-62-3.mol

Synonyms:1-(5-nitro-2-furyl)-3-(2-nitrophenyl)-2-propen-1-one;1-(5-nitro-2-pyridinyl)piperazine hydrochloride;2-Propen-1-one,1-(5-nitro-2-furanyl)-3-(2-nitrophenyl);

Suppliers and Price of 1-(5-Nitropyridin-2-yl)-piperazine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 8 raw suppliers

Chemical Property of 1-(5-Nitropyridin-2-yl)-piperazine hydrochloride

Chemical Property:

PSA：73.98000
LogP:2.11840

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-(5-Nitropyridin-2-yl)-piperazine hydrochloride

There total 2 articles about 1-(5-Nitropyridin-2-yl)-piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 193902-78-2
tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

: 1185319-62-3
1-(5-nitro-2-pyridinyl)piperazine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1039/d0ra01348j

Reference yield:

: 4548-45-2
2-chloro-5-nitropyridine

: 1185319-62-3
1-(5-nitro-2-pyridinyl)piperazine hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 110 °C

2: hydrogenchloride / dichloromethane; 1,4-dioxane / 12 h / 0 - 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/d0ra01348j

Reference yield:

: 1185319-62-3
1-(5-nitro-2-pyridinyl)piperazine hydrochloride

: 2-bromo-6-chloro-N-(6-(4-(pyrazine-2-carbonyl)piperazin-1-yl)-pyridin-3-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 20 °C / 3102.97 Torr

3: N,N-dimethyl-formamide / 24 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1039/d0ra01348j