1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE

Base Information

• Chemical Name: 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE
• CAS No.: 193902-78-2
• Molecular Formula: C14H20 N4 O4
• Molecular Weight: 308.33
• Hs Code.: 2933990090
• Mol file: 193902-78-2.mol

Synonyms:1,1-Dimethylethyl4-(5-nitro-2-pyridinyl)-1-piperazinecarboxylate; 1-(tert-Butyloxycarbonyl)-4-(5-nitropyridin-2-yl)piperazine;4-(5-Nitropyridin-2-yl)piperazine-1-carboxylic acid tert-butyl ester;tert-Butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate

Chemical Property of 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE

Chemical Property:

• Vapor Pressure: 5.84E-09mmHg at 25°C
• Melting Point: 168-172 °C(lit.)
• Refractive Index: 1.562
• Boiling Point: 468.7°C at 760 mmHg
• PKA: 4.38±0.29(Predicted)
• Flash Point: 237.3°C
• PSA: 91.49000
• Density: 1.258g/cm³
• LogP: 2.57300

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(5-Nitropyridin-2-yl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE

There total 6 articles about 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-nitropyridine (4548-45-2) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate (193902-78-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 100 ℃; for 16h;

Reference yield: 98.0%

di-tert-butyl dicarbonate (24424-99-5) + 1-(5-nitro-2-pyridinyl)piperazine (82205-58-1) → tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate (193902-78-2)

Guidance literature:

With sodium carbonate;

DOI:10.1016/j.bmcl.2011.06.062

Reference yield: 93.0%

2-bromo-5-nitropyridine (4487-59-6) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(5-nitropyridin-2-yl)piperazine-1-carboxylate (193902-78-2)

Guidance literature:

With potassium carbonate; tetra-(n-butyl)ammonium iodide; In dimethyl sulfoxide; at 50 ℃; for 3h;

upstream raw materials:

2-bromo-5-nitropyridine

1-t-Butoxycarbonylpiperazine

2-chloro-5-nitropyridine

di-tert-butyl dicarbonate

Downstream raw materials:

4-(5-aminopyridin-2-yl)-N-(2-fluorophenyl)piperazine-1-carboxamide

4-(5-nitropyridin-2-yl)-N-(2-fluorophenyl)piperazine-1-carboxamide

N-(2-fluorophenyl)-4-(5-(3-methylbenzofuran-2-carboxamido)pyridin-2-yl)piperazine-1-carboxamide

C₂₁H₂₆N₄O₄

Refernces

• 1、 -. "SMALL MOLECULE INHIBITORS OF GALECTIN-3". Page/Page column 26-27. . Retrieved 2021/11/20.
• 2、 -. "TARGETED PROTEIN DEGRADATION". Page/Page column 327. . Retrieved 2020/07/14.